Phenotypes associated with this allele

• Allele Symbol: Zfp42^tm1.1Log
• Allele Name: targeted mutation 1.1, Lorraine J Gudas
• Allele ID: MGI:5289943
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp42^tm1.1Log/Zfp42^tm1.1Log	involves: 129S1/Sv * C57BL/6 * C57BL/6J	MGI:5289962

Genotype
MGI:5289962

hm1

• Allelic Composition: Zfp42^tm1.1Log/Zfp42^tm1.1Log
• Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:175380 )

N • mice exhibit normal ovaries

kinked sperm flagellum ( J:175380 )

♂ • just distal to the head

abnormal sperm head morphology ( J:175380 )

♂ • some sperm heads lack cytoplasmic content

decreased male germ cell number ( J:175380 )

♂ • mild to moderate in the seminiferous tubules

♂ • however, germ cell cell cycle is normal

oligozoospermia ( J:175380 )

♂ • at 4 to 6 months of age

testicular atrophy ( J:175380 )

♂ • mild

endocrine/exocrine glands

testicular atrophy ( J:175380 )

♂ • mild

cellular

kinked sperm flagellum ( J:175380 )

♂ • just distal to the head

abnormal sperm head morphology ( J:175380 )

♂ • some sperm heads lack cytoplasmic content

decreased male germ cell number ( J:175380 )

♂ • mild to moderate in the seminiferous tubules

♂ • however, germ cell cell cycle is normal

oligozoospermia ( J:175380 )

♂ • at 4 to 6 months of age