Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm3(H1/tetO-RNAi:Mir143)Jcbr}
• Allele Name: targeted mutation 3, Jens C Bruning
• Allele ID: MGI:5290071
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gt(ROSA)26Sor^tm3(H1/tetO-RNAi:Mir143)Jcbr/Gt(ROSA)26Sor^+	involves: 129S6/SvEvTac * C57BL/6	MGI:5295735

Genotype
MGI:5295735

ht1

• Allelic Composition: Gt(ROSA)26Sor^{tm3(H1/tetO-RNAi:Mir143)Jcbr}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:176266 )

N • doxycycline-treated mice exhibit normal energy homeostasis

increased circulating insulin level ( J:176266 )

• in fasting doxycycline-treated mice

impaired glucose tolerance ( J:176266 )

• in doxycycline-treated mice

insulin resistance ( J:176266 )

• in doxycycline-treated mice

growth/size/body

growth/size/body region phenotype ( J:176266 )

N • doxycycline-treated mice exhibit normal body weight

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:176266 )

N • pancreatic beta-cell morphology is normal