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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vldlrm1Btlr
mutation 1, Bruce Beutler
MGI:5290092
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vldlrm1Btlr/Vldlrm1Btlr C57BL/6J-Vldlrm1Btlr MGI:5290105
ht2
 		Vldlrm1Btlr/Vldlrtm1Her involves: 129S7/SvEvBrd * C57BL/6J MGI:5290106


Genotype
MGI:5290105
hm1
Allelic
Composition		 Vldlrm1Btlr/Vldlrm1Btlr
Genetic
Background		 C57BL/6J-Vldlrm1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vldlrm1Btlr mutation (0 available); any Vldlr mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina morphology ( J:176337 )
• with some areas of disruption by vascular-like cells in the retinal outer nuclear layer, subretinal space, and retinal pigment epithelium
• at 14 months, mice exhibit vessel-like cellular structures appear in the disorganized subretinal region near the retinal pigment epithelium layer unlike in wild-type mice
abnormal retina vasculature morphology ( J:176337 )
• mice exhibit intraretinal vascular growth beyond the outer plexiform layer unlike in wild-type mice
abnormal retina photoreceptor morphology ( J:176337 )
• at 2 months, some photoreceptor cells completely lose their outer and inner segments and the outer nuclear layer adjacent to the retinal pigment layer compared to in wild-type mice
retina photoreceptor degeneration ( J:176337 )
• severe at 14 months of age
abnormal retina pigment epithelium morphology ( J:176337 )
• disorganized with some areas of disruption by vascular-like cells
abnormal retina pigmentation ( J:176337 )
• depigmented patch with hyperfluorescent spots
abnormal retina outer nuclear layer morphology ( J:176337 )
• distorted with some areas of disruption by vascular-like cells

cardiovascular system
abnormal retina vasculature morphology ( J:176337 )
• mice exhibit intraretinal vascular growth beyond the outer plexiform layer unlike in wild-type mice

nervous system
abnormal retina photoreceptor morphology ( J:176337 )
• at 2 months, some photoreceptor cells completely lose their outer and inner segments and the outer nuclear layer adjacent to the retinal pigment layer compared to in wild-type mice
retina photoreceptor degeneration ( J:176337 )
• severe at 14 months of age

pigmentation
abnormal retina pigment epithelium morphology ( J:176337 )
• disorganized with some areas of disruption by vascular-like cells
abnormal retina pigmentation ( J:176337 )
• depigmented patch with hyperfluorescent spots




Genotype
MGI:5290106
ht2
Allelic
Composition		 Vldlrm1Btlr/Vldlrtm1Her
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vldlrm1Btlr mutation (0 available); any Vldlr mutation (69 available)
Vldlrtm1Her mutation (1 available); any Vldlr mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina vasculature morphology ( J:176337 )
• similar to in mice homozygous for either allele with abnormal vascular growth from the outer plexiform layer towards the subretinal space and retinal pigment epithelial layer

cardiovascular system
abnormal retina vasculature morphology ( J:176337 )
• similar to in mice homozygous for either allele with abnormal vascular growth from the outer plexiform layer towards the subretinal space and retinal pigment epithelial layer




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory