All Phenotypes Pax3<tm6.1(Pax8)Buck> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax3^{tm6.1(Pax8)Buck}/Pax3^{tm6.1(Pax8)Buck}	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:5291830
ht2	Pax3^{tm6.1(Pax8)Buck}/Pax3⁺	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:5291831
ht3	Pax3^{tm6.1(Pax8)Buck}/Pax3^tm6.2Buck	involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL	MGI:5291829

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:176192 )

• mice die between E13.5 and E15.5

embryo

abnormal neural crest cell migration ( J:176192 )

• at E12.5, axons and spinal ganglia are severely reduced compared to in control mice

abnormal neural tube morphology ( J:176192 )

• authors state that mice exhibit the same phenotype at E11.5 and other stages as in Pax3^Sp mice

spina bifida ( J:176192 )

• in all mice

abnormal somite development ( J:176192 )

• disorganized

muscle

abnormal muscle precursor cell migration ( J:176192 )

• absent in forelimbs at E10.5

abnormal muscle development ( J:176192 )

• authors state that mice exhibit the same phenotype at E11.5 and other stages as in Pax3^Sp mice

abnormal myotome development ( J:176192 )

abnormal dermomyotome development ( J:176192 )

• in the epaxial and hypaxial dermomyotome

absent skeletal muscle ( J:176192 )

• in the limb

nervous system

abnormal neural tube morphology ( J:176192 )

• authors state that mice exhibit the same phenotype at E11.5 and other stages as in Pax3^Sp mice

spina bifida ( J:176192 )

• in all mice

exencephaly ( J:176192 )

abnormal dorsal root ganglion morphology ( J:176192 )

• at E12.5, axons and spinal ganglia are severely reduced compared to in control mice

cellular

abnormal muscle precursor cell migration ( J:176192 )

• absent in forelimbs at E10.5

abnormal neural crest cell migration ( J:176192 )

• at E12.5, axons and spinal ganglia are severely reduced compared to in control mice

Allelic Composition	Pax3^{tm6.1(Pax8)Buck}/Pax3⁺
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3^{tm6.1(Pax8)Buck} mutation (0 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle development ( J:176192 )

• in the limb

abnormal myotome development ( J:176192 )

pigmentation

belly spot ( J:176192 )

• as in mice heterozygous for a null allele

integument

belly spot ( J:176192 )

• as in mice heterozygous for a null allele

Allelic Composition	Pax3^{tm6.1(Pax8)Buck}/Pax3^tm6.2Buck
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3^{tm6.1(Pax8)Buck} mutation (0 available); any Pax3 mutation (50 available)
Pax3^tm6.2Buck mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:176192 )

• authors state that mice exhibit the same phenotype at E11.5 and other stages as in Pax3^Sp mice

muscle

abnormal muscle development ( J:176192 )

• authors state that mice exhibit the same phenotype at E11.5 and other stages as in Pax3^Sp mice

nervous system

abnormal neural tube morphology ( J:176192 )

• authors state that mice exhibit the same phenotype at E11.5 and other stages as in Pax3^Sp mice

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