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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cytl1tm1Chun
targeted mutation 1, Jang-Soo Chun
MGI:5291960
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cytl1tm1Chun/Cytl1tm1Chun involves: 129S4/SvJae * C57BL/6 MGI:5291964


Genotype
MGI:5291964
hm1
Allelic
Composition		 Cytl1tm1Chun/Cytl1tm1Chun
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cytl1tm1Chun mutation (0 available); any Cytl1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increased susceptibility to induced arthritis in Cytl1tm1Chun/Cytl1tm1Chun mice

skeleton
skeleton phenotype ( J:175377 )
N
• mice exhibit normal endochondral ossification and bone deveploment
increased susceptibility to induced arthritis ( J:175377 )
• following destabilization of the medial meniscus surgery, mice exhibit increased osteoarthritic cartilage destruction compared with wild-type mice

growth/size/body
growth/size/body region phenotype ( J:175377 )
N
• mice exhibit normal postnatal growth

cardiovascular system
cardiovascular system phenotype ( J:175377 )
N
• mice exhibit normal heart development

respiratory system
respiratory system phenotype ( J:175377 )
N
• mice exhibit normal lung development

immune system
increased susceptibility to induced arthritis ( J:175377 )
• following destabilization of the medial meniscus surgery, mice exhibit increased osteoarthritic cartilage destruction compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory