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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cacna1ctm4Hfm
targeted mutation 4, Franz Hofmann
MGI:5291981
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cacna1ctm3Hfm/Cacna1ctm4Hfm
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:5291995


Genotype
MGI:5291995
cn1
Allelic
Composition		 Cacna1ctm3Hfm/Cacna1ctm4Hfm
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Cacna1ctm3Hfm mutation (1 available); any Cacna1c mutation (144 available)
Cacna1ctm4Hfm mutation (0 available); any Cacna1c mutation (144 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:175463 )
• mice die within 3 weeks of tamoxifen treatment

muscle
abnormal muscle electrophysiology ( J:175463 )
• vetricular cardiomyocytes from tamoxifen-treated mice exhibit reduced current-voltage relation of current compared with cells from control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory