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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nrktm1Mkom
targeted mutation 1, Masayuki Komada
MGI:5292103
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nrktm1Mkom/Nrktm1Mkom B6.129S4-Nrktm1Mkom MGI:5292104
ht2
Nrktm1Mkom/Nrk+ B6.129S4-Nrktm1Mkom MGI:5292106
ot3
Nrktm1Mkom/Y B6.129S4-Nrktm1Mkom MGI:5292105


Genotype
MGI:5292104
hm1
Allelic
Composition
Nrktm1Mkom/Nrktm1Mkom
Genetic
Background
B6.129S4-Nrktm1Mkom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrktm1Mkom mutation (0 available); any Nrk mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Enlarged placentas in Nrktm1Mkom/Nrktm1Mkom females

mortality/aging
• in 19 of 56 cases when birthing null mice
• secondary to delayed delivery when born to homozygous dams
• null mice transplanted into wild-type dams exhibit delayed delivery and are born dead
• some mice die between birth and weaning

embryo
• the spongiotrophoblast layer is larger and invades into the labyrinth layer unlike in wild-type mice
• at E12.5
• at late gestation
• 2.2-fold heavier at E18.5

reproductive system
• null mice transplanted into wild-type dams exhibit delayed delivery and are born dead
• particularly when birthing null mice
• however, mice exhibit normal progesterone withdrawal and estrogen drive




Genotype
MGI:5292106
ht2
Allelic
Composition
Nrktm1Mkom/Nrk+
Genetic
Background
B6.129S4-Nrktm1Mkom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrktm1Mkom mutation (0 available); any Nrk mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• overgrown when the allele is inherited paternally
• 1.7-fold heavier when the allele is inherited paternally




Genotype
MGI:5292105
ot3
Allelic
Composition
Nrktm1Mkom/Y
Genetic
Background
B6.129S4-Nrktm1Mkom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrktm1Mkom mutation (0 available); any Nrk mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• secondary to delayed delivery when born to homozygous dams
• null mice transplanted into wild-type dams exhibit delayed delivery and are born dead
• some mice die between birth and weaning

embryo
• the spongiotrophoblast layer is larger and invades into the labyrinth layer unlike in wild-type mice
• at E12.5
• at late gestation
• 2.2-fold heavier at E18.5





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory