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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nrktm1Mkom
targeted mutation 1, Masayuki Komada
MGI:5292103
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nrktm1Mkom/Nrktm1Mkom B6.129S4-Nrktm1Mkom MGI:5292104
ht2
 		Nrktm1Mkom/Nrk+ B6.129S4-Nrktm1Mkom MGI:5292106
ot3
 		Nrktm1Mkom/Y B6.129S4-Nrktm1Mkom MGI:5292105


Genotype
MGI:5292104
hm1
Allelic
Composition		 Nrktm1Mkom/Nrktm1Mkom
Genetic
Background		 B6.129S4-Nrktm1Mkom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrktm1Mkom mutation (0 available); any Nrk mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Enlarged placentas in Nrktm1Mkom/Nrktm1Mkom females

mortality/aging
pregnancy-related premature death ( J:175907 )
• in 19 of 56 cases when birthing null mice
neonatal lethality, incomplete penetrance ( J:175907 )
• secondary to delayed delivery when born to homozygous dams
• null mice transplanted into wild-type dams exhibit delayed delivery and are born dead
postnatal lethality, incomplete penetrance ( J:175907 )
• some mice die between birth and weaning

embryo
increased spongiotrophoblast size ( J:175907 )
• the spongiotrophoblast layer is larger and invades into the labyrinth layer unlike in wild-type mice
enlarged placenta ( J:175907 )
• at E12.5
increased placenta weight ( J:175907 )
• at late gestation
• 2.2-fold heavier at E18.5

reproductive system
dystocia ( J:175907 )
• null mice transplanted into wild-type dams exhibit delayed delivery and are born dead
• particularly when birthing null mice
• however, mice exhibit normal progesterone withdrawal and estrogen drive




Genotype
MGI:5292106
ht2
Allelic
Composition		 Nrktm1Mkom/Nrk+
Genetic
Background		 B6.129S4-Nrktm1Mkom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrktm1Mkom mutation (0 available); any Nrk mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
increased spongiotrophoblast size ( J:175907 )
• overgrown when the allele is inherited paternally
increased placenta weight ( J:175907 )
• 1.7-fold heavier when the allele is inherited paternally




Genotype
MGI:5292105
ot3
Allelic
Composition		 Nrktm1Mkom/Y
Genetic
Background		 B6.129S4-Nrktm1Mkom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrktm1Mkom mutation (0 available); any Nrk mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:175907 )
• secondary to delayed delivery when born to homozygous dams
• null mice transplanted into wild-type dams exhibit delayed delivery and are born dead
postnatal lethality, incomplete penetrance ( J:175907 )
• some mice die between birth and weaning

embryo
increased spongiotrophoblast size ( J:175907 )
• the spongiotrophoblast layer is larger and invades into the labyrinth layer unlike in wild-type mice
enlarged placenta ( J:175907 )
• at E12.5
increased placenta weight ( J:175907 )
• at late gestation
• 2.2-fold heavier at E18.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory