Phenotypes associated with this allele

• Allele Symbol: Nrg1^tm1Sabe
• Allele Name: targeted mutation 1, Shin-ichi Abe
• Allele ID: MGI:5292107
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nrg1^tm1Sabe/Nrg1^tm1Sabe Tg(Amh-cre/ERT)#Sabe/0	B6JJcl.Cg-Nrg1^tm1Sabe Tg(Amh-cre/ERT)#Sabe	MGI:5292112

Genotype
MGI:5292112

cn1

• Allelic Composition: Nrg1^tm1Sabe/Nrg1^tm1Sabe; Tg(Amh-cre/ERT)#Sabe/0
• Genetic Background: B6JJcl.Cg-Nrg1^tm1Sabe Tg(Amh-cre/ERT)#Sabe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal seminiferous tubule morphology ( J:175448 )

♂ • with vacant areas in tamoxifen-treated mice

small testis ( J:175448 )

♂ • in tamoxifen-treated mice

decreased testis weight ( J:175448 )

♂ • in tamoxifen-treated mice

abnormal spermatogenesis ( J:175448 )

♂ • development of type B spermatogonia to pre-leptotene primary spermatocytes is largely suppressed in tamoxifen-treated mice compared to in wild-type mice

azoospermia ( J:175448 )

♂ • tamoxifen-treated mice lack spermatogonia

abnormal male reproductive system physiology ( J:175448 )

♂ • cell proliferation in seminiferous tubules of tamoxifen-treated mice is decreased compared to in wild-type mice

abnormal male germ cell apoptosis ( J:175448 )

♂ • in tamoxifen-treated mice

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:175448 )

♂ • with vacant areas in tamoxifen-treated mice

small testis ( J:175448 )

♂ • in tamoxifen-treated mice

decreased testis weight ( J:175448 )

♂ • in tamoxifen-treated mice

cellular

azoospermia ( J:175448 )

♂ • tamoxifen-treated mice lack spermatogonia

abnormal male germ cell apoptosis ( J:175448 )

♂ • in tamoxifen-treated mice