Phenotypes associated with this allele

• Allele Symbol: Cox15^tm1.1Zev
• Allele Name: targeted mutation 1.1, Massimo Zeviani
• Allele ID: MGI:5292113
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cox15^tm1.1Zev/Cox15^tm1.1Zev Tg(ACTA1-cre)79Jme/0	involves: 129 * C57BL/6 * C57BL/6J * SJL	MGI:5292122

Genotype
MGI:5292122

cn1

• Allelic Composition: Cox15^tm1.1Zev/Cox15^tm1.1Zev; Tg(ACTA1-cre)79Jme/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:176080 )

• in mice treated with bezafibrate

muscle

abnormal muscle fiber mitochondrial morphology ( J:176080 )

• in muscle cells

• reduced with AICAR treatment

increased variability of skeletal muscle fiber size ( J:176080 )

• in mice treated with bezafibrate

centrally nucleated skeletal muscle fibers ( J:176080 )

• in mice treated with bezafibrate

myopathy ( J:176080 )

• in mice treated with bezafibrate

cellular

abnormal muscle fiber mitochondrial morphology ( J:176080 )

• in muscle cells

• reduced with AICAR treatment

abnormal cellular respiration ( J:176080 )

• mitochondria in muscle cells exhibit increased cellular respiration compared with wild-type cells

increased mitochondrial fission ( J:176080 )

• compensatory in muscle cells

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:176080 )

• by P30, mice exhibit extremely reduced motor performance on a standard treadmill compared with wild-type mice

• treatment with AICAR does not improve motor performance

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:176080 )

• in mice treated with bezafibrate

increased physiological sensitivity to xenobiotic ( J:176080 )

• mice treated with bezafibrate exhibit increased mitochondrial myopathy, apoptosis, and lethality compared with similarly treated wild-type mice