All Phenotypes Psen1<tm1.1Tcs> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Psen1^tm1.1Tcs
targeted mutation 1.1, Takaomi C Saido
MGI:5292236

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Psen1^tm1.1Tcs/Psen1^tm1.1Tcs	involves: C57BL/6J	MGI:5292243
ht2	Psen1^tm1Shn/Psen1^tm1.1Tcs	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5292244
cx3	Psen1^tm1.1Tcs/Psen1^tm1.1Tcs Tg(APPSWE)2576Kha/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:5292246

Allelic Composition	Psen1^tm1.1Tcs/Psen1^tm1.1Tcs
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1^tm1.1Tcs mutation (0 available); any Psen1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:175901 )

• at E15 to E18

limbs/digits/tail

abnormal limb development ( J:175901 )

• limb ateliosis

short tail ( J:175901 )

• stubby

cardiovascular system

hemorrhage ( J:175901 )

• in the central nervous system

growth/size/body

decreased fetal size ( J:175901 )

Allelic Composition	Psen1^tm1Shn/Psen1^tm1.1Tcs
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1^tm1.1Tcs mutation (0 available); any Psen1 mutation (48 available)
Psen1^tm1Shn mutation (2 available); any Psen1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:175901 )

limbs/digits/tail

abnormal limb development ( J:175901 )

• limb ateliosis

short tail ( J:175901 )

• stubby

cardiovascular system

hemorrhage ( J:175901 )

• in the central nervous system

growth/size/body

decreased fetal size ( J:175901 )

Allelic Composition	Psen1^tm1.1Tcs/Psen1^tm1.1Tcs Tg(APPSWE)2576Kha/0
Genetic Background	involves: C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1^tm1.1Tcs mutation (0 available); any Psen1 mutation (48 available)
Tg(APPSWE)2576Kha mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal short-term spatial reference memory ( J:175901 )

• at 3 to 4 months in a Y-maze test

nervous system

amyloid beta deposits ( J:175901 )

• beginning at 6 months, earlier than in Tg(APPSWE)2576Kha mice at 12 months

• fewer plaques than in Psen1^tm1Mpm/Psen1^tm1Mpm Tg(APPSWE)2576Kha mice

astrocytosis ( J:175901 )

• at 9 months

homeostasis/metabolism

amyloid beta deposits ( J:175901 )

• beginning at 6 months, earlier than in Tg(APPSWE)2576Kha mice at 12 months

• fewer plaques than in Psen1^tm1Mpm/Psen1^tm1Mpm Tg(APPSWE)2576Kha mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24