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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad21ltm1Amp
targeted mutation 1, Alberto M Pendas
MGI:5292341
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rad21ltm1Amp/Rad21ltm1Amp B6.Cg-Rad21ltm1Amp MGI:5566677
hm2
 		Rad21ltm1Amp/Rad21ltm1Amp involves: 129S6/SvEvTac * C57BL/6NCr MGI:5292347


Genotype
MGI:5566677
hm1
Allelic
Composition		 Rad21ltm1Amp/Rad21ltm1Amp
Genetic
Background		 B6.Cg-Rad21ltm1Amp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21ltm1Amp mutation (0 available); any Rad21l mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:205574 )
• defect in telomere-nuclear envelope attachment

cellular
abnormal male meiosis ( J:205574 )
• defect in telomere-nuclear envelope attachment




Genotype
MGI:5292347
hm2
Allelic
Composition		 Rad21ltm1Amp/Rad21ltm1Amp
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21ltm1Amp mutation (0 available); any Rad21l mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:176168 )
• mice lack spermatozoa in the epididymides
abnormal female meiosis ( J:176168 )
• pachytene oocytes exhibit slight defects in synapsis compared to in wild-type cells
abnormal male meiosis ( J:176168 )
• spermatocytes exhibit discontinuous and fragmented stretches of axial and alteral element and deficient synapsis compared to in wild-type cells
• okadaic acid-treated spermatocytes exhibit unattached univalents unlike in similarly treated wild-type spermatocytes
abnormal synaptonemal complex ( J:176168 )
• spermatocytes exhibit discontinuous and fragmented stretches of axial and alteral element and deficient synapsis compared to in wild-type cells
• pachytene oocytes exhibit slight defects in synapsis compared to in wild-type cells
abnormal male germ cell apoptosis ( J:176168 )
• by stage IV of spermatogenesis
ovary fibrosis ( J:176168 )
• fibrotic
arrest of male meiosis ( J:176168 )
• at zygotene
reduced female fertility ( J:176168 )
• female mice produce fewer pups per litter compared with wild-type female mice
decreased litter size ( J:176168 )
• female mice produce fewer pups per litter compared with wild-type female mice

homeostasis/metabolism

cellular
azoospermia ( J:176168 )
• mice lack spermatozoa in the epididymides
abnormal telomere morphology ( J:176168 )
• in spermatocytes, telomere attachement to the nuclear envelope is partially misregulated compared to in wild-type spermatocytes
abnormal female meiosis ( J:176168 )
• pachytene oocytes exhibit slight defects in synapsis compared to in wild-type cells
abnormal male meiosis ( J:176168 )
• spermatocytes exhibit discontinuous and fragmented stretches of axial and alteral element and deficient synapsis compared to in wild-type cells
• okadaic acid-treated spermatocytes exhibit unattached univalents unlike in similarly treated wild-type spermatocytes
arrest of male meiosis ( J:176168 )
• at zygotene
abnormal synaptonemal complex ( J:176168 )
• spermatocytes exhibit discontinuous and fragmented stretches of axial and alteral element and deficient synapsis compared to in wild-type cells
• pachytene oocytes exhibit slight defects in synapsis compared to in wild-type cells
abnormal male germ cell apoptosis ( J:176168 )
• by stage IV of spermatogenesis

endocrine/exocrine glands
ovary fibrosis ( J:176168 )
• fibrotic




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory