Phenotypes associated with this allele

• Allele Symbol: Nr5a1^tm1.1Hain
• Allele Name: targeted mutation 1.1, Holly A Ingraham
• Allele ID: MGI:5292676
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr5a1^tm1.1Hain/Nr5a1^tm1.1Hain	Not Specified	MGI:5292677
ht2	Nr5a1^tm1.1Hain/Nr5a1^+	Not Specified	MGI:5292678
cx3	Nr5a1^tm1.1Hain/Nr5a1^tm1.1Hain Shh^tm1Amc/Shh^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5292679

Genotype
MGI:5292677

hm1

• Allelic Composition: Nr5a1^tm1.1Hain/Nr5a1^tm1.1Hain
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

oligozoospermia ( J:175843 )

♂

retention of the adrenal gland x-zone ( J:175843 )

• persistence of fetal X-zone

mortality/aging

mortality/aging ( J:175843 )

N • unlike null mice, mice are viable

reproductive system

oligozoospermia ( J:175843 )

♂

abnormal testis morphology ( J:175843 )

♂

seminiferous tubule degeneration ( J:175843 )

♂

abnormal testis development ( J:175843 )

♂ • irregularly branched, thin cords are seen as early as E13.5

increased Leydig cell number ( J:175843 )

♂

decreased testis weight ( J:175843 )

♂ • dramatic reduction in testicular weight

infertility ( J:175843 )

female infertility ( J:175843 )

♀

male infertility ( J:175843 )

♂

homeostasis/metabolism

abnormal aldosterone level ( J:175843 )

• decreased adrenal aldosterone levels

abnormal corticosterone level ( J:175843 )

• elevated adrenal corticosterone level

abnormal progesterone level ( J:175843 )

• elevated testicular progesterone levels

abnormal testosterone level ( J:175843 )

• elevated testicular testosterone levels

endocrine/exocrine glands

retention of the adrenal gland x-zone ( J:175843 )

• persistence of fetal X-zone

small adrenal glands ( J:175843 )

• significant but subtle decrease in weight

abnormal testis morphology ( J:175843 )

♂

seminiferous tubule degeneration ( J:175843 )

♂

abnormal testis development ( J:175843 )

♂ • irregularly branched, thin cords are seen as early as E13.5

increased Leydig cell number ( J:175843 )

♂

decreased testis weight ( J:175843 )

♂ • dramatic reduction in testicular weight

Genotype
MGI:5292678

ht2

• Allelic Composition: Nr5a1^tm1.1Hain/Nr5a1⁺
• Genetic Background: Not Specified

endocrine/exocrine glands

retention of the adrenal gland x-zone ( J:175843 )

• persistence of fetal X-zone

cellular

retention of the adrenal gland x-zone ( J:175843 )

• persistence of fetal X-zone

Genotype
MGI:5292679

cx3

• Allelic Composition: Nr5a1^tm1.1Hain/Nr5a1^tm1.1Hain; Shh^tm1Amc/Shh⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

homeostasis/metabolism

abnormal aldosterone level ( J:175843 )

• decreased adrenal aldosterone levels

• decrease is less severe than in mice homozygous for Nr5a1^tm1.1Hain alone