All Phenotypes Capn2<tm1Tcs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Capn2^tm1Tcs
targeted mutation 1, Takaomi C Saido
MGI:5292734

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Capn2^tm1Tcs/Capn2^tm1Tcs	B6.129S-Capn2^tm1Tcs	MGI:5292740
cn2	Capn1^tm1Ahc/Capn1^tm1Ahc Capn2^tm1Tcs/Capn2^tm2.1Tcs Meox2^tm1(cre)Sor/Meox2⁺	B6.129-Capn2^tm1Tcs/Capn2^tm2.1Tcs Meox2^tm1(cre)Sor Capn1^tm1Ahc	MGI:5292738
cn3	Capn2^tm1Tcs/Capn2^tm2.1Tcs Meox2^tm1(cre)Sor/Meox2⁺	B6.129S-Capn2^tm1Tcs/Capn2^tm2.1Tcs Meox2^tm1(cre)Sor	MGI:5292736
cx4	Capn1^tm1Ahc/Capn1^tm1Ahc Capn2^tm1Tcs/Capn2^tm1Tcs	B6.129-Capn2^tm1Tcs Capn1^tm1Ahc	MGI:5292739
cx5	Capn2^tm1Tcs/Capn2^tm1Tcs Cast^tm1Tcs/Cast^tm1Tcs	B6.129-Capn2^tm1Tcs Cast^tm1Tcs	MGI:5292741
cx6	Capn1^tm1Ahc/Capn1^tm1Ahc Capn2^tm1Tcs/Capn2^tm1Tcs Cast^tm1Tcs/Cast^tm1Tcs	B6.129-Capn2^tm1Tcs Cast^tm1Tcs Capn1^tm1Ahc	MGI:5292742

Allelic Composition	Capn2^tm1Tcs/Capn2^tm1Tcs
Genetic Background	B6.129S-Capn2^tm1Tcs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn2^tm1Tcs mutation (1 available); any Capn2 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:175868 )

• most die between E14.5 and E15.5

prenatal lethality, complete penetrance ( J:175868 )

embryo

pale placenta ( J:175868 )

• at E13.5 in 4 of 10 mice

cardiovascular system

abnormal vascular development ( J:175868 )

• failure of peripheral vessels in the limb and head regions from E15.5

thin ventricular wall ( J:175868 )

• in 1 of 3 and 3 of 3 mice at E14.5 and E15.5

abnormal blood circulation ( J:175868 )

• blood flow in the placental labyrinth is reduced

Allelic Composition	Capn1^tm1Ahc/Capn1^tm1Ahc Capn2^tm1Tcs/Capn2^tm2.1Tcs Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	B6.129-Capn2^tm1Tcs/Capn2^tm2.1Tcs Meox2^tm1(cre)Sor Capn1^tm1Ahc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn1^tm1Ahc mutation (1 available); any Capn1 mutation (33 available)
Capn2^tm1Tcs mutation (1 available); any Capn2 mutation (35 available)
Capn2^tm2.1Tcs mutation (1 available); any Capn2 mutation (35 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

abnormal survival ( J:175868 )

• about half survive to adulthood

Allelic Composition	Capn2^tm1Tcs/Capn2^tm2.1Tcs Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	B6.129S-Capn2^tm1Tcs/Capn2^tm2.1Tcs Meox2^tm1(cre)Sor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn2^tm1Tcs mutation (1 available); any Capn2 mutation (35 available)
Capn2^tm2.1Tcs mutation (1 available); any Capn2 mutation (35 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

abnormal survival ( J:175868 )

• about half survive to adulthood

Allelic Composition	Capn1^tm1Ahc/Capn1^tm1Ahc Capn2^tm1Tcs/Capn2^tm1Tcs
Genetic Background	B6.129-Capn2^tm1Tcs Capn1^tm1Ahc

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:175868 )

• die around E11.5 - E12.5

embryo

abnormal placenta labyrinth morphology ( J:175868 )

• reduced development

• apoptotic trophoblasts are detected in the labyrinthine region

pale placenta ( J:175868 )

• at E11.5

cardiovascular system

thin ventricular wall ( J:175868 )

• at E11.5

abnormal blood circulation ( J:175868 )

• blood flow in the placental labyrinth is reduced

Allelic Composition	Capn2^tm1Tcs/Capn2^tm1Tcs Cast^tm1Tcs/Cast^tm1Tcs
Genetic Background	B6.129-Capn2^tm1Tcs Cast^tm1Tcs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn2^tm1Tcs mutation (1 available); any Capn2 mutation (35 available)
Cast^tm1Tcs mutation (1 available); any Cast mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

abnormal survival ( J:175868 )

• probability of survival is reduced by about 50%

Allelic Composition	Capn1^tm1Ahc/Capn1^tm1Ahc Capn2^tm1Tcs/Capn2^tm1Tcs Cast^tm1Tcs/Cast^tm1Tcs
Genetic Background	B6.129-Capn2^tm1Tcs Cast^tm1Tcs Capn1^tm1Ahc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn1^tm1Ahc mutation (1 available); any Capn1 mutation (33 available)
Capn2^tm1Tcs mutation (1 available); any Capn2 mutation (35 available)
Cast^tm1Tcs mutation (1 available); any Cast mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:175868 )

• die around E11.5

cardiovascular system

hemorrhage ( J:175868 )

• detected in the trunk region

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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