Phenotypes associated with this allele

• Allele Symbol: Tslp^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:5292857
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tslp^tm1(KOMP)Vlcg/Tslp^tm1(KOMP)Vlcg	involves: C57BL/6 * C57BL/6NTac	MGI:5438831

Genotype
MGI:5438831

hm1

• Allelic Composition: Tslp^{tm1(KOMP)Vlcg}/Tslp^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 2 cell differentiation ( J:187770 )

• LPS-induced Th2 polarization of bone marrow-derived dendritic cells is impaired

abnormal immune system physiology ( J:187770 )

• mice exhibit impaired low dose LPS-induced Th2 sensitization

• however, mice exhibit normal high dose LPS-induced Th1 sensitization

abnormal immunoglobulin level ( J:187770 )

• mice treated with low dose LPS fail to exhibit airway hyperresponsiveness or increased serum IgE unlike wild-type mice

decreased circulating interleukin-4 level ( J:187770 )

• in the bronchoalveolar lavage fluid of mice stimulated with high dose of LPS

increased interferon-gamma secretion ( J:187770 )

• in the bronchoalveolar lavage fluid of mice stimulated with high dose of LPS

decreased acute inflammation ( J:187770 )

• mice treated with low dose LPS fail to exhibit airway hyperresponsiveness or increased serum IgE unlike wild-type mice

• however, high dose LPS results in airway inflammation

respiratory system inflammation ( J:187770 )

• mice treated with a high dose of LPS exhibit a neutrophil-dominant infiltration in the airways compared with an eosinophil-dominant infiltration in wild-type mice

respiratory system

respiratory system inflammation ( J:187770 )

• mice treated with a high dose of LPS exhibit a neutrophil-dominant infiltration in the airways compared with an eosinophil-dominant infiltration in wild-type mice

abnormal airway responsiveness ( J:187770 )

• mice treated with low dose LPS fail to exhibit airway hyperresponsiveness or increased serum IgE unlike wild-type mice

homeostasis/metabolism

decreased circulating interleukin-4 level ( J:187770 )

• in the bronchoalveolar lavage fluid of mice stimulated with high dose of LPS

hematopoietic system

abnormal T-helper 2 cell differentiation ( J:187770 )

• LPS-induced Th2 polarization of bone marrow-derived dendritic cells is impaired

abnormal immunoglobulin level ( J:187770 )

• mice treated with low dose LPS fail to exhibit airway hyperresponsiveness or increased serum IgE unlike wild-type mice