Analysis Tools
homeostasis/metabolism
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• mice show no differences in oxygen consumption, respiratory exchange ratio, food and water intake, physical activity, core body temperature or fecal fat excretion
• plasma glucose and insulin levels in the fasted and fed states are not altered in mutants and mice fed a high-fat diet for 11 weeks exhibit a similar increase of insulin to glucose ratio and glucose tolerance like wild-type mice
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• 70% reduction in plasma triglyceride levels when fed a chow diet ad libitum
• plasma triglyceride levels are reduced in fed but not in fasted mutants
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• 40% reduction in plasma nonesterified fatty acid levels when fed a chow diet ad libitum
• however, mice on a 12 hour fasting/12 hour feeding cycle for 3 days, do not exhibit a difference in plasma noesterified fatty acid levels
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• chow-fed mutants show an increase in heparin-releasable lipoprotein lipase activity
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• reduction in VLDL triglyceride secretion
• in oral fat tolerance tests, mutants show attenuated excursion of plasma triglyceride levels following an oil gavage, indicating accelerated clearance of dietary fat
• the feeding-induced increase in VLDL-triglyceride uptake by adipose tissue that is seen in wild-type mice is abolished in mutants
• however, hepatic steatosis is not seen
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adipose tissue
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• small decrease in body fat content is seen by 12 weeks of age
• decreased body weight is entirely attributed to a reduced accumulation of adipose tissue
• lean mass is normal
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• small decrease in percent body fat is seen by 12 weeks of age
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growth/size/body
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• after 12 weeks of age
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• after 12 weeks of age, mutants fail to gain weight at the same rate as wild-type mice
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