Phenotypes associated with this allele

• Allele Symbol: Selenof^tm1Vgla
• Allele Name: targeted mutation 1, Vadim N Gladyshev
• Allele ID: MGI:5293082
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Selenof^tm1Vgla/Selenof^tm1Vgla	involves: 129 * C57BL/6	MGI:5293103

Genotype
MGI:5293103

hm1

• Allelic Composition: Selenof^tm1Vgla/Selenof^tm1Vgla
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Selenof^tm1Vgla/Selenof^tm1Vgla mice develop cataracts

vision/eye

lens vacuoles ( J:176744 )

• extensive vacuolization

abnormal lens fiber morphology ( J:176744 )

• aberrant structure of fiber cells

cataract ( J:176744 )

• as early as 1.5 months of age

• increasing in size with age

nuclear cataract ( J:176744 )

• predominantly

liver/biliary system

abnormal liver physiology ( J:176744 )

• livers exhibit increased lipid and protein oxidation indicating mild oxidative stress compared with wild-type livers

cellular

cellular phenotype ( J:176744 )

N • mouse embryonic fibroblasts exhibit normal unfolded protein response

oxidative stress ( J:176744 )

• mild in the liver