Phenotypes associated with this allele

• Allele Symbol: Apba3^tm1.2Ski
• Allele Name: targeted mutation 1.2, Motoharu Seiki
• Allele ID: MGI:5293147
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apba3^tm1.2Ski/Apba3^tm1.2Ski	B6.129-Apba3^tm1.2Ski	MGI:5293173

Genotype
MGI:5293173

hm1

• Allelic Composition: Apba3^tm1.2Ski/Apba3^tm1.2Ski
• Genetic Background: B6.129-Apba3^tm1.2Ski

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:176742 )

• in LPS-treated mice

immune system

abnormal macrophage physiology ( J:176742 )

• macrophage exhibit reduced motility and invasiveness compared with wild-type cells

• bone marrow-derived and peritoneal macrophages produce less ATP and lactate than wild-type mice

decreased circulating interleukin-12 level ( J:176742 )

• in LPS-treated mice

decreased circulating tumor necrosis factor level ( J:176742 )

• in LPS-treated mice

decreased interleukin-12 secretion ( J:176742 )

• from LPS-stimulated macrophage

decreased tumor necrosis factor secretion ( J:176742 )

• from LPS-stimulated macrophage

decreased susceptibility to endotoxin shock ( J:176742 )

• LPS-treated mice exhibit increased survival and decreased TNF-alpha and IL12 serum levels compared with similarly treated wild-type mice

homeostasis/metabolism

decreased circulating interleukin-12 level ( J:176742 )

• in LPS-treated mice

decreased circulating tumor necrosis factor level ( J:176742 )

• in LPS-treated mice

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:176742 )

• in LPS-treated mice

hematopoietic system

abnormal macrophage physiology ( J:176742 )

• macrophage exhibit reduced motility and invasiveness compared with wild-type cells

• bone marrow-derived and peritoneal macrophages produce less ATP and lactate than wild-type mice