All Phenotypes Slc13a5<tm1.2Helf> MGI Mouse

increased lean body mass ( J:176732 )

• increase in the proportion of lean body mass by 11% at 8 months of age

decreased body weight ( J:176732 )

• body weight is 10% lower on a regular chow diet at 4 weeks of age compared to wild-type mice

decreased body length ( J:176732 )

• at 3 months of age

abnormal susceptibility to weight gain ( J:176732 )

decreased susceptibility to age related obesity ( J:176732 )

decreased susceptibility to diet-induced obesity ( J:176732 )

• decreased weight gain on a high fat diet compared to wild-type mice

decreased total body fat amount ( J:176732 )

• the proportion of fat mass to body weight is markedly reduced in mice on a high fat diet

• fat mass is reduced by 45% in chow fed mice at 8 months of age

decreased circulating lactate level ( J:176732 )

• plasma lactate concentrations are reduced in mice on a high fat diet

increased energy expenditure ( J:176732 )

• on a normal chow or high fat diet

decreased susceptibility to diet-induced obesity ( J:176732 )

• decreased weight gain on a high fat diet compared to wild-type mice

increased carbon dioxide production ( J:176732 )

increased oxygen consumption ( J:176732 )

abnormal glucose homeostasis ( J:176732 )

• endogenous glucose production is reduced

decreased circulating glucose level ( J:176732 )

• basal plasma glucose is reduced

decreased circulating insulin level ( J:176732 )

• basal plasma insulin is reduced

improved glucose tolerance ( J:176732 )

• glycemic excursion and plasma insulin excursion are reduced in intraperitoneal glucose tolerance tests

increased insulin sensitivity ( J:176732 )

• preserved insulin sensitivity at 8 months of age compared to age matched wild-type controls

abnormal glycerol level ( J:176732 )

• decrease in hepatic and muscle diacylglycerol concentrations

decreased liver triglyceride level ( J:176732 )

abnormal metabolism ( J:176732 )

• rates of nonoxidative glucose metabolism tend to be increased in mice on a high fat diet and are significantly higher in older mice

• whole body glucose metabolism is increased during an hyperinsulinemic-euglycemic clamp

abnormal liver morphology ( J:176732 )

• markedly reduced liver lipid content in mice on a high fat diet

• decrease in hepatic diacylglycerol concentrations

abnormal hepatocyte mitochondrial morphology ( J:176732 )

• mitochondrial density is increased in hepatocytes

decreased liver triglyceride level ( J:176732 )

abnormal liver physiology ( J:176732 )

• show a 20% reduction in hepatic citrate uptake

• decrease in lipid generation

• analysis indicates hepatic lipid peroxidation is increased by 62%

• oxygen consumption is increased in liver homogenates

abnormal hepatocyte physiology ( J:176732 )

• lipid oxidation is increased and citrate uptake is reduced in primary hepatocytes

• hepatic ATP concentration is reduced

increased locomotor activity ( J:176732 )

• increase in locomotor activity during the first 3?4 hr of food ingestion

abnormal muscle physiology ( J:176732 )

• decrease in muscle diacylglycerol concentrations

increased skeletal muscle cell glucose uptake ( J:176732 )

• peripheral glucose uptake by the gastrocnemius muscle is increased

abnormal hepatocyte mitochondrial morphology ( J:176732 )

• mitochondrial density is increased in hepatocytes

increased skeletal muscle cell glucose uptake ( J:176732 )

• peripheral glucose uptake by the gastrocnemius muscle is increased

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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