Phenotypes associated with this allele

• Allele Symbol: Capns1^tm1.1Otsu
• Allele Name: targeted mutation 1.1, Kinya Otsu
• Allele ID: MGI:5293309
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Capns1^tm1.1Otsu/Capns1^tm1.1Otsu Tg(Myh6-cre)2182Mds/0	involves: C57BL/6J * FVB/N	MGI:5293311

Genotype
MGI:5293311

cn1

• Allelic Composition: Capns1^tm1.1Otsu/Capns1^tm1.1Otsu; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased cardiac fibrosis in Capns1^tm1.1Otsu/Capns1^tm1.1Otsu Tg(Myh6-cre)2182Mds/0 mice after transverse aortic constriction

cardiovascular system

abnormal heart left ventricle morphology ( J:176736 )

• in response to pressure overload or isoproterenol treatment, mice exhibit increased end-diastolic and end-systolic LV internal dimension compared with similarly treated wild-type mice

dilated heart left ventricle ( J:176736 )

• 2 weeks after isoproterenol treatment

cardiac fibrosis ( J:176736 )

• in response to pressure overload

decreased cardiac muscle contractility ( J:176736 )

• in response to pressure overload or isoproterenol treatment

abnormal myocardial fiber physiology ( J:176736 )

• mice exposed to pressure overload exhibit plasma membrane in heart sarcolemma compared with similarly treated wild-type mice

• heart sarcolemma exhibit defective membrane damage repair compared with similarly treated wild-type mice

increased response of heart to induced stress ( J:176736 )

• in response to pressure overload, mice exhibit congestive heart failure (increased end-diastolic and end-systolic LV internal dimension, decreased fractional shortening, and increased lung weight to body weight) compared with similarly treated wild-type mice

• mice treated with isoproterenol exhibit congestive heart failure (increased end-diastolic and end-systolic LV internal dimension, decreased fractional shortening, increased heart weight, and increased lung weight to body weight) compared with similarly treated wild-type mice

congestive heart failure ( J:176736 )

• in response to pressure overload or isoproterenol treatment

respiratory system

increased lung weight ( J:176736 )

• in response to pressure overload or isoproterenol treatment

homeostasis/metabolism

increased response of heart to induced stress ( J:176736 )

• in response to pressure overload, mice exhibit congestive heart failure (increased end-diastolic and end-systolic LV internal dimension, decreased fractional shortening, and increased lung weight to body weight) compared with similarly treated wild-type mice

• mice treated with isoproterenol exhibit congestive heart failure (increased end-diastolic and end-systolic LV internal dimension, decreased fractional shortening, increased heart weight, and increased lung weight to body weight) compared with similarly treated wild-type mice

muscle

decreased cardiac muscle contractility ( J:176736 )

• in response to pressure overload or isoproterenol treatment

growth/size/body

increased lung weight ( J:176736 )

• in response to pressure overload or isoproterenol treatment