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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkab2tm1Grst
targeted mutation 1, Gregory R Steinberg
MGI:5293372
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Prkab1tm1Grst/Prkab1tm1Grst
Prkab2tm1Grst/Prkab2tm1Grst
Tg(Ckmm-cre)5Khn/0 		involves: C57BL/6 * FVB MGI:5293380
cn2
 		Prkab2tm1Grst/Prkab2tm1Grst
Tg(Ckmm-cre)5Khn/0 		involves: C57BL/6 * FVB MGI:5293381


Genotype
MGI:5293380
cn1
Allelic
Composition		 Prkab1tm1Grst/Prkab1tm1Grst
Prkab2tm1Grst/Prkab2tm1Grst
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkab1tm1Grst mutation (0 available); any Prkab1 mutation (24 available)
Prkab2tm1Grst mutation (1 available); any Prkab2 mutation (29 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
decreased muscle cell glucose uptake ( J:176578 )
• decreased glucose uptake during exercise
abnormal skeletal muscle morphology ( J:176578 )
• decrease in intermyofibrillar mitochondrial content
• mitochondria in both the intermyofibrillar and subsarcolemmal regions are larger
increased muscle fatigability ( J:176578 )
• isolated EDL muscles fatigue rapidly

behavior/neurological
decreased locomotor activity ( J:176578 )
• decrease in voluntary wheel activity
impaired exercise endurance ( J:176578 )
• exercise intolerant and have dramatic reductions in both maximal running speed and distance covered

homeostasis/metabolism
impaired exercise endurance ( J:176578 )
• exercise intolerant and have dramatic reductions in both maximal running speed and distance covered
increased circulating glucose level ( J:176578 )
• elevated serum glucose following exercise
abnormal enzyme/coenzyme activity ( J:176578 )
• decrease in citrate synthase and cytochrome c oxidase activities

cellular
decreased muscle cell glucose uptake ( J:176578 )
• decreased glucose uptake during exercise




Genotype
MGI:5293381
cn2
Allelic
Composition		 Prkab2tm1Grst/Prkab2tm1Grst
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkab2tm1Grst mutation (1 available); any Prkab2 mutation (29 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired exercise endurance ( J:176578 )
• about a 25% reduction in running capacity

behavior/neurological
impaired exercise endurance ( J:176578 )
• about a 25% reduction in running capacity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory