All Phenotypes Cyld<tm1.1Mpa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cyld^tm1.1Mpa
targeted mutation 1.1, Manolis Pasparakis
MGI:5293377

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cyld^tm1.1Mpa/Cyld^tm1.1Mpa Ikbkg^tm1.1Mpa/Ikbkg^tm1.1Mpa Tg(Vil1-cre)997Gum/0	B6.Cg-Cyld^tm1.1Mpa Ikbkg^tm1.1Mpa Tg(Vil1-cre)997Gum	MGI:5293401
cn2	Cyld^tm1.1Mpa/Cyld^tm1.1Mpa Ikbkg^tm1.1Mpa/Y Tg(Vil1-cre)997Gum/0	B6.Cg-Cyld^tm1.1Mpa Ikbkg^tm1.1Mpa Tg(Vil1-cre)997Gum	MGI:5293402
cn3	Cyld^tm1.1Mpa/Cyld^tm1.1Mpa Fadd^tm1Mpa/Fadd^tm1Mpa Tg(Vil1-cre)997Gum/0	B6.Cg-Fadd^tm1Mpa Cyld^tm1.1Mpa Tg(Vil1-cre)997Gum	MGI:5293400

Allelic Composition	Cyld^tm1.1Mpa/Cyld^tm1.1Mpa Ikbkg^tm1.1Mpa/Ikbkg^tm1.1Mpa Tg(Vil1-cre)997Gum/0
Genetic Background	B6.Cg-Cyld^tm1.1Mpa Ikbkg^tm1.1Mpa Tg(Vil1-cre)997Gum

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyld^tm1.1Mpa mutation (0 available); any Cyld mutation (44 available)
Ikbkg^tm1.1Mpa mutation (1 available); any Ikbkg mutation (16 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

crypts of Lieberkuhn abscesses ( J:175865 )

colitis ( J:175865 )

• as in Ikbkg^tm1.1Mpa/Ikbkg^tm1.1Mpa Tg(Vil-cre)997Gum

endocrine/exocrine glands

crypts of Lieberkuhn abscesses ( J:175865 )

immune system

colitis ( J:175865 )

• as in Ikbkg^tm1.1Mpa/Ikbkg^tm1.1Mpa Tg(Vil-cre)997Gum

Allelic Composition	Cyld^tm1.1Mpa/Cyld^tm1.1Mpa Ikbkg^tm1.1Mpa/Y Tg(Vil1-cre)997Gum/0
Genetic Background	B6.Cg-Cyld^tm1.1Mpa Ikbkg^tm1.1Mpa Tg(Vil1-cre)997Gum

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

crypts of Lieberkuhn abscesses ( J:175865 )

colitis ( J:175865 )

• as in Ikbkg^tm1.1Mpa/Ikbkg^tm1.1Mpa Tg(Vil-cre)997Gum

endocrine/exocrine glands

crypts of Lieberkuhn abscesses ( J:175865 )

immune system

colitis ( J:175865 )

• as in Ikbkg^tm1.1Mpa/Ikbkg^tm1.1Mpa Tg(Vil-cre)997Gum

Allelic Composition	Cyld^tm1.1Mpa/Cyld^tm1.1Mpa Fadd^tm1Mpa/Fadd^tm1Mpa Tg(Vil1-cre)997Gum/0
Genetic Background	B6.Cg-Fadd^tm1Mpa Cyld^tm1.1Mpa Tg(Vil1-cre)997Gum

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyld^tm1.1Mpa mutation (0 available); any Cyld mutation (44 available)
Fadd^tm1Mpa mutation (0 available); any Fadd mutation (18 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:175865 )

N	• mice do not develop colitis

decreased Paneth cell number ( J:175865 )

• reduced numbers

cecum inflammation ( J:175865 )

endocrine/exocrine glands

decreased Paneth cell number ( J:175865 )

• reduced numbers

immune system

cecum inflammation ( J:175865 )

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