Phenotypes associated with this allele

• Allele Symbol: Fstl1^{tm2.1(cre/ERT2)Mvdh}
• Allele Name: targeted mutation 2.1, Maurice JB van den Hoff
• Allele ID: MGI:5293378
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fstl1^tm2.1(cre/ERT2)Mvdh/Fstl1^tm2.1(cre/ERT2)Mvdh	involves: 129P2/OlaHsd * C57BL/6	MGI:5297488
ht2	Fstl1^tm2.1(cre/ERT2)Mvdh/Fstl1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5297489

Genotype
MGI:5297488

hm1

• Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:176532 )

respiratory system

abnormal lung lobe morphology ( J:176532 )

• late embryonic lungs have abnormal, bubble-shaped lobes instead of the pyramidal shape in controls

abnormal pulmonary alveolus morphology ( J:176532 )

• distal alveolar airspaces have tight, focal structure

primary atelectasis ( J:176532 )

• no lung inflation is detected in any homozygous animals after birth

abnormal bronchiole morphology ( J:176532 )

• proximal bronchioles are irregular and enlarged in mutant lungs

abnormal tracheal cartilage morphology ( J:176532 )

• some tracheal rings are poorly spaced whereas others are hypoplastic in E18.5 animals

respiratory distress ( J:176532 )

• animals begin gasping immediately after birth and die within minutes

limbs/digits/tail

fused phalanges ( J:176532 )

camptomelia ( J:176532 )

• bending (campomelia) of the radius, ulna, humerus, femur and fibula is observed at E18.5

• campomelia is present by E13.5

skeleton

fused phalanges ( J:176532 )

camptomelia ( J:176532 )

• bending (campomelia) of the radius, ulna, humerus, femur and fibula is observed at E18.5

• campomelia is present by E13.5

abnormal tracheal cartilage morphology ( J:176532 )

• some tracheal rings are poorly spaced whereas others are hypoplastic in E18.5 animals

asymmetric sternocostal joints ( J:176532 )

• rib-sternum mispairing is observed (asymmetric attachment of ribs to sternum and shifted ossification centers)

abnormal costal cartilage morphology ( J:176532 )

• cartilaginous processes are present at the ventral part of the first five ribs

abnormal rib morphology ( J:176532 )

homeostasis/metabolism

cyanosis ( J:176532 )

• at birth coloration changes from pink to purple, with death occurring in minutes

Genotype
MGI:5297489

ht2

• Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

skeleton

asymmetric sternocostal joints ( J:176532 )

• rib-sternum mispairing is observed with greater prominence than what is observed in homozygotes

abnormal rib morphology ( J:176532 )