Phenotypes associated with this allele

• Allele Symbol: Tg(CEPHY152F7)12Hgc
• Allele Name: transgene insertion 12, Edward M Rubin
• Allele ID: MGI:5293446
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CEPHY152F7)12Hgc/0	(C57BL/6 x FVB/N)F1	MGI:5320166
tg2	Tg(CEPHY152F7)12Hgc/0	FVB-Tg(CEPHY152F7)12Hgc	MGI:5320174

Genotype
MGI:5320166

tg1

• Allelic Composition: Tg(CEPHY152F7)12Hgc/0
• Genetic Background: (C57BL/6 x FVB/N)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:128896 )

• in the Morris water maze, mutants spend an equal amount of time exploring the quadrant of the pool where the platform had been formerly located, however they cross significantly less frequently over the site of the original platform

• in the reverse platform test, mutants fail to show a significant decrease in latency to find the invisible platform as in controls

• in the reverse probe test, mutants perform much worse than controls, spending substantially less time in the quadrant of the pool where the reversed platform had been located and crossing the position of the platform much less frequently

decreased locomotor activity ( J:128896 )

nervous system

nervous system phenotype ( J:128896 )

N • mutants exhibit normal long term potentiation and paired-pulse facilitation

Genotype
MGI:5320174

tg2

• Allelic Composition: Tg(CEPHY152F7)12Hgc/0
• Genetic Background: FVB-Tg(CEPHY152F7)12Hgc

behavior/neurological

abnormal emotion/affect behavior ( J:128896 )

• upon initial handling, mutants react similarly to controls, however they become increasingly more agitated with continued handling

abnormal reflex ( J:128896 )

• mutants show a tendency to curl into a ball when lifted by the tail