Phenotypes associated with this allele

• Allele Symbol: Noa1^tm1Tze
• Allele Name: targeted mutation 1, Tomasz Zemojtel
• Allele ID: MGI:5293450
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Noa1^tm1Tze/Noa1^tm1Tze	involves: 129P2/OlaHsd * C57BL/6	MGI:5293682

Genotype
MGI:5293682

hm1

• Allelic Composition: Noa1^tm1Tze/Noa1^tm1Tze
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:176798 )

• no viable embryos are observed at E10.5

cellular

abnormal mitochondrial morphology ( J:176798 )

• embryos exhibit abnormal mitochondria with swollen cristae

abnormal mitochondrial crista morphology ( J:176798 )

• swollen

abnormal cell physiology ( J:176798 )

• primary fibroblasts grown under nutrient restriction exhibit reduced viability and cellular ATP compared with similarly treated wild-type cells

decreased sensitivity to induced cell death ( J:176798 )

• cells exhibit resistance to straurosporine-induced apoptosis compared with similarly treated wild-type cells

decreased apoptosis ( J:176798 )

• in E9.5 embryos

decreased embryonic tissue cell apoptosis ( J:176798 )

• in E9.5 embryos

abnormal mitochondrial physiology ( J:176798 )

• mitochondrial protein synthesis is compromised compared to in wild-type cells

abnormal mitochondrial ATP synthesis coupled electron transport ( J:176798 )

• digitonin-permeabilized primary fibroblasts exhibit severe reduction in complex I, III, and IV-dependent oxygen consumption, indicating a global OXPHOS defect, compared with similarly treated wild-type mice

embryo

decreased embryonic tissue cell apoptosis ( J:176798 )

• in E9.5 embryos

embryonic growth retardation ( J:176798 )

• at E9.5, only 9 somites are observed

embryo tissue necrosis ( J:176798 )

• E10.5 embryos are necrotic

abnormal trophoblast layer morphology ( J:176798 )

• all three trophoblast layers, including the trophoblast giant cell layer, are reduced compared to in wild-type mice

growth/size/body

embryonic growth retardation ( J:176798 )

• at E9.5, only 9 somites are observed