Phenotypes associated with this allele

• Allele Symbol: Mir34a^tm1Hher
• Allele Name: targeted mutation 1, Heiko Hermeking
• Allele ID: MGI:5293762
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir34a^tm1Hher/Mir34a^tm1Hher	involves: 129 * C57BL/6	MGI:5615148

Genotype
MGI:5615148

hm1

• Allelic Composition: Mir34a^tm1Hher/Mir34a^tm1Hher
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:209587 )

• upon azoxymethane/dextran sodium sulfate (AOM/DSS) challenge, the incidence and size of tumors are increased in mutants compared to similarly treated controls

• tumors exhibit increased cell proliferation and decreased apoptosis compared to control tumors

• about 70% of mice show invasive tumors that penetrate through the muscularis mucosa which is not seen in control tumors

• mice, however, do not display any obvious phenotype or an increase in spontaneous tumor formation

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:209587 )

• upon azoxymethane/dextran sodium sulfate (AOM/DSS) challenge, the incidence and size of tumors are increased in mutants compared to similarly treated controls

• tumors exhibit increased cell proliferation and decreased apoptosis compared to control tumors

• about 70% of mice show invasive tumors that penetrate through the muscularis mucosa which is not seen in control tumors

• mice, however, do not display any obvious phenotype or an increase in spontaneous tumor formation