About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad21tm1.1Mmk
targeted mutation 1.1, Matthias Merkenschlager
MGI:5293824
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rad21tm1.1Mmk/Rad21tm1.1Mmk
Tg(Cd4-cre)1Cwi/0 		involves: 129 * C57BL/6 MGI:5293828


Genotype
MGI:5293828
cn1
Allelic
Composition		 Rad21tm1.1Mmk/Rad21tm1.1Mmk
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21tm1.1Mmk mutation (0 available); any Rad21 mutation (60 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:175827 )
• double positive thymocyte differentiation is impaired compared to in control mice
• however, double positive thymocyte survival is normal
decreased double-positive T cell number ( J:175827 )
• until 6 weeks of age, intermediate CD4+ CD8lo cells accumulate more slowly than in control mice
decreased CD8-positive, alpha-beta T cell number ( J:175827 )
• until 6 weeks of age, mature CD4+ cells accumulate more slowly than in control mice
abnormal CD4-positive, alpha beta T cell morphology ( J:175827 )
• CD4 single positive thymocytes exhibit abnormal mitotic figures with multiple spindles, chromosome segregation defects and poor survival compared with control cells
decreased CD4-positive, alpha-beta T cell number ( J:175827 )
• until 6 weeks of age, mature CD4+ cells accumulate more slowly than in control mice

hematopoietic system
abnormal T cell differentiation ( J:175827 )
• double positive thymocyte differentiation is impaired compared to in control mice
• however, double positive thymocyte survival is normal
decreased double-positive T cell number ( J:175827 )
• until 6 weeks of age, intermediate CD4+ CD8lo cells accumulate more slowly than in control mice
decreased CD8-positive, alpha-beta T cell number ( J:175827 )
• until 6 weeks of age, mature CD4+ cells accumulate more slowly than in control mice
abnormal CD4-positive, alpha beta T cell morphology ( J:175827 )
• CD4 single positive thymocytes exhibit abnormal mitotic figures with multiple spindles, chromosome segregation defects and poor survival compared with control cells
decreased CD4-positive, alpha-beta T cell number ( J:175827 )
• until 6 weeks of age, mature CD4+ cells accumulate more slowly than in control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory