Phenotypes associated with this allele

• Allele Symbol: Ptpn22^tm1.1Kas
• Allele Name: targeted mutation 1.1, Katherine A Siminovitch
• Allele ID: MGI:5294241
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpn22^tm1.1Kas/Ptpn22^tm1.1Kas	involves: C57BL/6	MGI:5294245
cx2	Ptpn22^tm1.1Kas/Ptpn22^tm1.1Kas Tg(TcraTcrb)425Cbn/0	involves: BALB/c * C57BL/6	MGI:5294247
cx3	Ptpn22^tm1.1Kas/Ptpn22^tm1.1Kas Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: C57BL/6 * C57BL/6J * DBA/2J	MGI:5294246

Genotype
MGI:5294245

hm1

• Allelic Composition: Ptpn22^tm1.1Kas/Ptpn22^tm1.1Kas
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:176519 )

N • mice exhibit normal early T cell development, B cell development, and auto-antibody levels

increased B cell proliferation ( J:176519 )

• in the spleen in response to both T-cell-dependent and -independent antigen-receptor stimulation but not LPS

increased T cell proliferation ( J:176519 )

• in response to TCR stimulation and enhanced and prolonged Lck and ZAP-70 tyrosine phosphorylation

enlarged thymus ( J:176519 )

• beginning at 2 months

enlarged spleen ( J:176519 )

• beginning at 2 months

increased dendritic cell number ( J:176519 )

• in the spleen at 3 to 8 months of age

increased T cell number ( J:176519 )

• in the thymus, spleen, and lymph nodes

increased CD4-positive, alpha-beta T cell number ( J:176519 )

• effector/memory T cells (CD44^hi CD62^low) in the spleen and lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:176519 )

• effector/memory T cells (CD44^hi CD62^low) in the spleen and lymph nodes

increased spleen germinal center number ( J:176519 )

• in response to both T-cell-dependent and -independent antigen-receptor stimulation but not LPS

increased spleen germinal center size ( J:176519 )

• in response to both T-cell-dependent and -independent antigen-receptor stimulation but not LPS

increased IgG2a level ( J:176519 )

• anti-NP

increased IgG3 level ( J:176519 )

• anti-TNP

increased IgM level ( J:176519 )

• anti-TNP

abnormal dendritic cell physiology ( J:176519 )

• dendritic cells pulsed with ovalbumin and co-cultured with CD4+ Tg(TcraTcrb)425Cbn Y cells exhibit increased proliferation compared with similarly treated wild-type cells

increased interleukin-12 secretion ( J:176519 )

• in LPS-stimulated bone marrow-derived dendritic cells

hematopoietic system

increased B cell proliferation ( J:176519 )

• in the spleen in response to both T-cell-dependent and -independent antigen-receptor stimulation but not LPS

increased T cell proliferation ( J:176519 )

• in response to TCR stimulation and enhanced and prolonged Lck and ZAP-70 tyrosine phosphorylation

enlarged thymus ( J:176519 )

• beginning at 2 months

enlarged spleen ( J:176519 )

• beginning at 2 months

increased dendritic cell number ( J:176519 )

• in the spleen at 3 to 8 months of age

increased T cell number ( J:176519 )

• in the thymus, spleen, and lymph nodes

increased CD4-positive, alpha-beta T cell number ( J:176519 )

• effector/memory T cells (CD44^hi CD62^low) in the spleen and lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:176519 )

• effector/memory T cells (CD44^hi CD62^low) in the spleen and lymph nodes

increased spleen germinal center number ( J:176519 )

• in response to both T-cell-dependent and -independent antigen-receptor stimulation but not LPS

increased spleen germinal center size ( J:176519 )

• in response to both T-cell-dependent and -independent antigen-receptor stimulation but not LPS

increased IgG2a level ( J:176519 )

• anti-NP

increased IgG3 level ( J:176519 )

• anti-TNP

increased IgM level ( J:176519 )

• anti-TNP

endocrine/exocrine glands

enlarged thymus ( J:176519 )

• beginning at 2 months

cellular

increased B cell proliferation ( J:176519 )

• in the spleen in response to both T-cell-dependent and -independent antigen-receptor stimulation but not LPS

increased T cell proliferation ( J:176519 )

• in response to TCR stimulation and enhanced and prolonged Lck and ZAP-70 tyrosine phosphorylation

growth/size/body

enlarged spleen ( J:176519 )

• beginning at 2 months

Genotype
MGI:5294247

cx2

• Allelic Composition: Ptpn22^tm1.1Kas/Ptpn22^tm1.1Kas; Tg(TcraTcrb)425Cbn/0
• Genetic Background: involves: BALB/c * C57BL/6

immune system

increased T cell proliferation ( J:176519 )

• in naive spleen and lymph node in response to TCR stimulation and enhanced and prolonged Lck and ZAP-70 tyrosine phosphorylation

increased CD4-positive, alpha-beta T cell number ( J:176519 )

• mice exhibit increased positive selection of thymic and peripheral T cells compared with wild-type mice

hematopoietic system

increased T cell proliferation ( J:176519 )

• in naive spleen and lymph node in response to TCR stimulation and enhanced and prolonged Lck and ZAP-70 tyrosine phosphorylation

increased CD4-positive, alpha-beta T cell number ( J:176519 )

• mice exhibit increased positive selection of thymic and peripheral T cells compared with wild-type mice

cellular

increased T cell proliferation ( J:176519 )

• in naive spleen and lymph node in response to TCR stimulation and enhanced and prolonged Lck and ZAP-70 tyrosine phosphorylation

Genotype
MGI:5294246

cx3

• Allelic Composition: Ptpn22^tm1.1Kas/Ptpn22^tm1.1Kas; Tg(TcraH-Y,TcrbH-Y)71Vbo/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2J

immune system

immune system phenotype ( J:176519 )

N • mice exhibit normal positive selection of thymic and peripheral T cells compared with wild-type mice