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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pnpla2tm1Eek
targeted mutation 1, Erin E Kershaw
MGI:5294351
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pnpla2tm1Eek/Pnpla2tm1Eek
Tg(Myog-cre)1Eno/0 		involves: 129S * C57BL/6 MGI:5554580
cn2
 		Pnpla2tm1Eek/Pnpla2tm1Eek
Tg(Ckmm-cre)5Khn/0 		involves: 129S * FVB/N MGI:5294403


Genotype
MGI:5554580
cn1
Allelic
Composition		 Pnpla2tm1Eek/Pnpla2tm1Eek
Tg(Myog-cre)1Eno/0
Genetic
Background		 involves: 129S * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnpla2tm1Eek mutation (1 available); any Pnpla2 mutation (33 available)
Tg(Myog-cre)1Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid level ( J:207007 )
• increase in diacylglycerol levels (specifically subspecies C14:0/16:0, C14:0/18:0, C16:0/18:0) in skeletal muscle in mice fed both chow and high fat diet as compared to control
increased fatty acids level ( J:207007 )
• increase in fatty acid-CoA levels (specifically subspecies C14:0, C16:0) in mice fed both chow and high fat diet as compared to controls
increased skeletal muscle triglyceride level ( J:207007 )
• increase in intramyocellular triacylglycerol (IMTG) levels in skeletal muscle; increase is specific to muscle fiber type (2A>2X>1, but not 2B)
• IMTG levels are increased in mice fed both chow and high fat diet as compared to controls

muscle
increased skeletal muscle triglyceride level ( J:207007 )
• increase in intramyocellular triacylglycerol (IMTG) levels in skeletal muscle; increase is specific to muscle fiber type (2A>2X>1, but not 2B)
• IMTG levels are increased in mice fed both chow and high fat diet as compared to controls




Genotype
MGI:5294403
cn2
Allelic
Composition		 Pnpla2tm1Eek/Pnpla2tm1Eek
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnpla2tm1Eek mutation (1 available); any Pnpla2 mutation (33 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased cardiac muscle triglyceride level ( J:176252 )
• 10.7-fold in cardiac muscle

growth/size/body
increased heart weight ( J:176252 )
• 1.5-fold

homeostasis/metabolism
increased cardiac muscle triglyceride level ( J:176252 )
• 10.7-fold in cardiac muscle

muscle
increased cardiac muscle triglyceride level ( J:176252 )
• 10.7-fold in cardiac muscle




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory