Analysis Tools
mortality/aging
|
• between 5 and 7 months of age often due to feeding difficulties
|
nervous system
|
• the amyloid beta load peaks at 7 months of age while the pyroglutamate amyloid beta load peaks at 4 weeks of age
|
|
• neuronal loss is seen at 3 months of age in the CA1 pyramidal cell layer
• loss of more than 40% of neurons in the rostral hippocampal CA1 region
|
|
• loss of almost 50% of pyramidal neurons in the CA1 pyramidal cell layer by 5 months of age
|
|
• loss of almost 50% of pyramidal neurons in the CA1 pyramidal cell layer by 5 months of age
|
microgliosis
(
J:176575
)
|
• at 2 and 3 months of age
• reduced at 5 months of age
|
astrocytosis
(
J:176575
)
|
• progressive age dependent astrocytosis beginning at 2 months of age
|
|
• decreased fEPSP
|
|
• at 5 months of age
|
|
• dramatic loss detectable at P28
|
behavior/neurological
|
• onset of behavioral phenotypes at 4 weeks of age
|
|
• progressive decline in home cage free drinking behavior with age
|
|
• progressive decline in home cage free feeding behavior with age
|
|
• delayed
|
|
• display cramping or tremors when lifted by the tail
|
|
• performance on a rotarod is less than 20% that of wild-type controls
|
|
• abnormal posture and rigor at 3 months of age
|
|
• progressive decline with age
|
growth/size/body
|
• about 30% lower compared to wild-type controls at 4.5 months of age
|
|
• detectable at 4 weeks of age
|
hematopoietic system
microgliosis
(
J:176575
)
|
• at 2 and 3 months of age
• reduced at 5 months of age
|
immune system
microgliosis
(
J:176575
)
|
• at 2 and 3 months of age
• reduced at 5 months of age
|
homeostasis/metabolism
|
• the amyloid beta load peaks at 7 months of age while the pyroglutamate amyloid beta load peaks at 4 weeks of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:176575 | ||
