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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd8atm1.1(cre)Koni
targeted mutation 1.1, Pandelakis A Koni
MGI:5294414
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd8atm1.1(cre)Koni/Cd8atm1.1(cre)Koni involves: C57BL/6J * C57BL/6NHsd * SJL MGI:5294425
ht2
Cd8atm1.1(cre)Koni/Cd8a+ involves: C57BL/6J * C57BL/6NHsd * SJL MGI:5294424


Genotype
MGI:5294425
hm1
Allelic
Composition
Cd8atm1.1(cre)Koni/Cd8atm1.1(cre)Koni
Genetic
Background
involves: C57BL/6J * C57BL/6NHsd * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1.1(cre)Koni mutation (1 available); any Cd8a mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice have greatly reduced numbers of CD8 T cells, with only 13% of wild-type level of Cd8a expression

immune system
• mice have greatly reduced numbers of CD8 T cells, with only 13% of wild-type level of Cd8a expression




Genotype
MGI:5294424
ht2
Allelic
Composition
Cd8atm1.1(cre)Koni/Cd8a+
Genetic
Background
involves: C57BL/6J * C57BL/6NHsd * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1.1(cre)Koni mutation (1 available); any Cd8a mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable, fertile, and normal in size

hematopoietic system
N
• mice have normal numbers of CD8 T cells in lymphoid organs, despite a 35% reduction of Cd8a expression





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory