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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k12tm1.1Lewc
targeted mutation 1.1, Joseph W Lewcock
MGI:5294468
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map3k12tm1.1Lewc/Map3k12tm1.1Lewc Not Specified MGI:5294552
cx2
 		Map3k12tm1.1Lewc/Map3k12tm1.1Lewc
Tg(Mnx1-GFP)1Slp/0 		Not Specified MGI:5294553


Genotype
MGI:5294552
hm1
Allelic
Composition		 Map3k12tm1.1Lewc/Map3k12tm1.1Lewc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k12tm1.1Lewc mutation (0 available); any Map3k12 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased neuron apoptosis ( J:176956 )
• in culture following NGF withdrawal
• 1.7-fold at E15.5 in the dorsal root ganglia
abnormal neuron differentiation ( J:176956 )
• in culture, dorsal root ganglia exhibit reduced axon degeneration following NGF withdrawal compared with wild-type cells
• however, dorsal root ganglia axon outgrowth is normal
abnormal dorsal root ganglion morphology ( J:176956 )
• increase in number 1.8-fold at E17.5

cellular
decreased neuron apoptosis ( J:176956 )
• in culture following NGF withdrawal
• 1.7-fold at E15.5 in the dorsal root ganglia
abnormal neuron differentiation ( J:176956 )
• in culture, dorsal root ganglia exhibit reduced axon degeneration following NGF withdrawal compared with wild-type cells
• however, dorsal root ganglia axon outgrowth is normal




Genotype
MGI:5294553
cx2
Allelic
Composition		 Map3k12tm1.1Lewc/Map3k12tm1.1Lewc
Tg(Mnx1-GFP)1Slp/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k12tm1.1Lewc mutation (0 available); any Map3k12 mutation (39 available)
Tg(Mnx1-GFP)1Slp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:176956 )
N
• motor and sensory axon outgrowth is normal
increased motor neuron number ( J:176956 )
• doubled at E15.5 and E17.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory