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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tet3tm1.2Gxu
targeted mutation 1.2, Guo-Liang Xu
MGI:5294564
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tet3tm1.1Gxu/Tet3tm1.2Gxu
Tg(Zp3-cre)3Mrt/0 		involves: 129 * C57BL/6J * FVB/N * SJL MGI:5294568
cn2
 		Alpltm1(cre)Nagy/Alpl+
Tet3tm1.1Gxu/Tet3tm1.2Gxu 		involves: 129 * C57BL/6J * SJL MGI:5294565


Genotype
MGI:5294568
cn1
Allelic
Composition		 Tet3tm1.1Gxu/Tet3tm1.2Gxu
Tg(Zp3-cre)3Mrt/0
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet3tm1.1Gxu mutation (0 available); any Tet3 mutation (60 available)
Tet3tm1.2Gxu mutation (0 available); any Tet3 mutation (60 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA methylation ( J:176196 )
• paternal genome reprogramming is impaired in offspring of mutant females
maternal effect ( J:176196 )
• paternal genome reprogramming is impaired in offspring of mutant females
• inheriting the mutant allele maternally impairs embryonic survival




Genotype
MGI:5294565
cn2
Allelic
Composition		 Alpltm1(cre)Nagy/Alpl+
Tet3tm1.1Gxu/Tet3tm1.2Gxu
Genetic
Background		 involves: 129 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1(cre)Nagy mutation (6 available); any Alpl mutation (352 available)
Tet3tm1.1Gxu mutation (0 available); any Tet3 mutation (60 available)
Tet3tm1.2Gxu mutation (0 available); any Tet3 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced female fertility ( J:176196 )
• decrease in frequency of successful pregnancy per mating and litter size when crossed to wild-type males

cellular
abnormal DNA methylation ( J:176196 )
• paternal genome reprogramming is impaired in offspring of mutant females
maternal effect ( J:176196 )
• paternal genome reprogramming is impaired in offspring of mutant females
• inheriting the mutant allele maternally impairs embryonic survival




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory