All Phenotypes Lin28a<tm1Gqda> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lin28a^tm1Gqda
targeted mutation 1, George Q Daley
MGI:5294611

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lin28a^tm1Gqda/Lin28a^tm1.1Gqda Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N	MGI:5519072
cn2	Lin28a^tm1Gqda/Lin28a^tm1Gqda Myf5^tm1(cre)Mrc/Myf5⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5519078
cn3	Lin28a^tm1Gqda/Lin28a^tm1Gqda Myf5^tm3(cre)Sor/Myf5⁺	involves: 129S4/SvJae * C57BL/6 * CD-1	MGI:5294786

Allelic Composition	Lin28a^tm1Gqda/Lin28a^tm1.1Gqda Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1.1Gqda mutation (1 available); any Lin28a mutation (76 available)
Lin28a^tm1Gqda mutation (0 available); any Lin28a mutation (76 available)
Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mutation (6 available); any Ndor1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:199720 )

N	• mice exhibit normal growth when treated with tamoxifen at 7 to 9 days or 6 weeks of age

decreased body size ( J:199720 )

• dwarfism in male mice treated with tamoxifen at E15.5, but not as severe as in Lin28a^tm1.1Gqda homozygotes

• however, female mice exhibit normal growth

decreased body length ( J:199720 )

• dwarfism in male mice treated with tamoxifen at E15.5

• however, female mice exhibit normal growth

Allelic Composition	Lin28a^tm1Gqda/Lin28a^tm1Gqda Myf5^tm1(cre)Mrc/Myf5⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1Gqda mutation (0 available); any Lin28a mutation (76 available)
Myf5^tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:199720 )

N	• mice exhibit normal size

Allelic Composition	Lin28a^tm1Gqda/Lin28a^tm1Gqda Myf5^tm3(cre)Sor/Myf5⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28a^tm1Gqda mutation (0 available); any Lin28a mutation (76 available)
Myf5^tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired glucose tolerance ( J:177113 )

insulin resistance ( J:177113 )

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