All Phenotypes Col1a1<tm3(tetO-Mirlet7g/Mir21)Gqda> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}
targeted mutation 3, George Q Daley
MGI:5294613

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/Col1a1⁺	involves: 129S4/SvJae * C57BL/6	MGI:5569527
cn2	Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/Col1a1⁺ Myf5^tm1(cre)Mrc/Myf5⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5519077
cn3	Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺ Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5638880
cx4	Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/? Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺	involves: 129S4/SvJae * C57BL/6	MGI:5500065
cx5	Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺	involves: 129S4/SvJae * C57BL/6 * CD-1	MGI:5294615
cx6	Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺	involves: 129S4/SvJae * C57BL/6 * CD-1	MGI:5294616

Allelic Composition	Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/Col1a1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} mutation (1 available); any Col1a1 mutation (161 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuronal stem cell self-renewal ( J:207231 )

• reduced multipotent neurospheres, neurosphere size and self-renewal potential in doxycycline-treated mice

Allelic Composition	Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/Col1a1⁺ Myf5^tm1(cre)Mrc/Myf5⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} mutation (1 available); any Col1a1 mutation (161 available)
Myf5^tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:199720 )

• dwarfism in male and female mice

decreased body length ( J:199720 )

Allelic Composition	Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺ Wt1^{tm2(cre/ERT2)Wtp}/Wt1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm2(tetO-LIN28B)Gqda} mutation (1 available); any Col1a1 mutation (161 available)
Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} mutation (1 available); any Col1a1 mutation (161 available)
Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy} mutation (5 available); any Gt(ROSA)26Sor mutation (968 available)
Wt1^{tm2(cre/ERT2)Wtp} mutation (1 available); any Wt1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

small kidney ( J:211179 )

• small kidney in mice induced with doxycycline from E14.5 until the end of the experiment

• however, cap mesenchyme differentiates normally in doxycycline induced mutants

Allelic Composition	Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/? Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} mutation (1 available); any Col1a1 mutation (161 available)
Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} mutation (30 available); any Gt(ROSA)26Sor mutation (968 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased primordial germ cell number ( J:196313 )

• in doxycycline-treated neonates

cellular

decreased primordial germ cell number ( J:196313 )

• in doxycycline-treated neonates

Allelic Composition	Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda}/Col1a1⁺ Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} mutation (1 available); any Col1a1 mutation (161 available)
Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} mutation (30 available); any Gt(ROSA)26Sor mutation (968 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:177113 )

• following doxycycline treatment

postnatal growth retardation ( J:177113 )

• following doxycycline treatment

homeostasis/metabolism

increased circulating glucose level ( J:177113 )

• in the fed state following doxycycline treatment

increased circulating insulin level ( J:177113 )

• during a glucose tolerance test in doxycycline treated mice

• however, no difference in insulin sensitivity is detected following doxycycline treatment

impaired glucose tolerance ( J:177113 )

• following doxycycline treatment on a normal or high fat diet

Allelic Composition	Col1a1^{tm2(tetO-LIN28B)Gqda}/Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm2(tetO-LIN28B)Gqda} mutation (1 available); any Col1a1 mutation (161 available)
Col1a1^{tm3(tetO-Mirlet7g/Mir21)Gqda} mutation (1 available); any Col1a1 mutation (161 available)
Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae} mutation (30 available); any Gt(ROSA)26Sor mutation (968 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:177113 )

N	• following doxycycline treatment responses in a glucose tolerance test are similar to controls

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