Phenotypes associated with this allele

• Allele Symbol: Liph^tm1Aoki
• Allele Name: targeted mutation 1, Junken Aoki
• Allele ID: MGI:5294787
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Liph^tm1Aoki/Liph^tm1Aoki	B6JJcl.129S-Liph^tm1Aoki	MGI:5294789

Genotype
MGI:5294789

hm1

• Allelic Composition: Liph^tm1Aoki/Liph^tm1Aoki
• Genetic Background: B6JJcl.129S-Liph^tm1Aoki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal coat/ hair morphology ( J:177192 )

• from 1 to 4 weeks of age, pelage hairs exhibit waviness, disorganized medulla, irregular melanin piles, and wavy cuticles

• pelage hair defects are less severe after the start of the anagen phase of the first hair cycle

• however, mice do not develop alopecia

abnormal hair shaft melanin granule morphology ( J:177192 )

• irregular melanin piles

matted coat ( J:177192 )

waved hair ( J:177192 )

abnormal hair cuticle ( J:177192 )

• wavy

abnormal hair medulla ( J:177192 )

• disorganized

abnormal hair follicle inner root sheath morphology ( J:177192 )

• the inner root sheath (IRS) is irregularly shaped with discontinuous Henle's layer and protruding Huxley's layer into the outer root sheath

• however, IRS length is normal

wavy vibrissae ( J:177192 )

pigmentation

abnormal hair shaft melanin granule morphology ( J:177192 )

• irregular melanin piles