pigmentation
• reduced tail pigmentation in mice on a black or agouti background
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• weak silvering effect in the coat color and reduced tail and paw pigmentation in mice on a black background
• marked dilution on a brown background
• on a brown agouti background dilution of the dark hairs is seen
• decrease in eumelanin content in the hair but no significant effect on pheomelanin content
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• skin, choroid, and retinal melanosomes are spherical
• no fibrillar intermediates are detected in melaocytes
• many of the melanosomes are associated with dense, granular deposits of melanin rather than the smooth, fibrillar deposits
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• spherical melanosomes
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• spherical melanosomes
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integument
• reduced tail pigmentation in mice on a black or agouti background
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• weak silvering effect in the coat color and reduced tail and paw pigmentation in mice on a black background
• marked dilution on a brown background
• on a brown agouti background dilution of the dark hairs is seen
• decrease in eumelanin content in the hair but no significant effect on pheomelanin content
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vision/eye
• spherical melanosomes
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• spherical melanosomes
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