All Phenotypes Lgr5<tm1(cre/ERT2)Fjs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lgr5^{tm1(cre/ERT2)Fjs}
targeted mutation 1, Frederick J de Sauvage
MGI:5294796

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lgr5^{tm1(cre/ERT2)Fjs}/Lgr5^{tm2(Hbegf/EGFP)Fjs} Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N	MGI:5298069

Allelic Composition	Lgr5^{tm1(cre/ERT2)Fjs}/Lgr5^{tm2(Hbegf/EGFP)Fjs} Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Lgr5^{tm1(cre/ERT2)Fjs} mutation (0 available); any Lgr5 mutation (58 available)
Lgr5^{tm2(Hbegf/EGFP)Fjs} mutation (1 available); any Lgr5 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:177145 )

• mice die at P1

digestive/alimentary system

digestive/alimentary phenotype ( J:177145 )

N	• despite loss of crypt basal columnar cells in diphtheria-treated E15 mice, intestinal epithelium homeostasis is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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