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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lgr5tm2(Hbegf/EGFP)Fjs
targeted mutation 2, Frederick J de Sauvage
MGI:5294798
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Lgr5tm2(Hbegf/EGFP)Fjs/Lgr5+ involves: C57BL/6N MGI:5298068
cn2
 		Lgr5tm1(cre/ERT2)Fjs/Lgr5tm2(Hbegf/EGFP)Fjs
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ 		involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N MGI:5298069


Genotype
MGI:5298068
ht1
Allelic
Composition		 Lgr5tm2(Hbegf/EGFP)Fjs/Lgr5+
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm2(Hbegf/EGFP)Fjs mutation (1 available); any Lgr5 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:177145 )
N
• diphtheria-treated mice exhibit normal intestinal epithelial migration




Genotype
MGI:5298069
cn2
Allelic
Composition		 Lgr5tm1(cre/ERT2)Fjs/Lgr5tm2(Hbegf/EGFP)Fjs
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (992 available)
Lgr5tm1(cre/ERT2)Fjs mutation (0 available); any Lgr5 mutation (58 available)
Lgr5tm2(Hbegf/EGFP)Fjs mutation (1 available); any Lgr5 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

digestive/alimentary system
digestive/alimentary phenotype ( J:177145 )
N
• despite loss of crypt basal columnar cells in diphtheria-treated E15 mice, intestinal epithelium homeostasis is normal




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory