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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdh5tm1Dvst
targeted mutation 1, Dietmar Vestweber
MGI:5294807
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cdh5tm1Dvst/Cdh5tm1Dvst
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 		involves: C57BL/6 * CBA MGI:7467143
cn2
 		Cdh5tm1Dvst/Cdh5tm1Dvst
Tg(Cdh5-cre/ERT2)1Rha/0 		Not Specified MGI:5445989


Genotype
MGI:7467143
cn1
Allelic
Composition		 Cdh5tm1Dvst/Cdh5tm1Dvst
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh5tm1Dvst mutation (0 available); any Cdh5 mutation (59 available)
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased angiogenesis ( J:328283 )
• delayed superficial blood vessel growth in retina at age P7 after tamoxifen administration from age P1-P4
increased angiogenesis ( J:328283 )
• local blood vessel hyperdensity in retina at age P7 after tamoxifen administration from age P1-P4
hemorrhage ( J:328283 )
• extensive blood leakage in retina at age P7 after tamoxifen administration from age P1-P4

vision/eye
abnormal retina development ( J:328283 )
• delayed superficial blood vessel growth at age P7 after tamoxifen administration from age P1-P4
• local blood vessel hyperdensity at age P7 after tamoxifen administration from age P1-P4
• extensive blood leakage at age P7 after tamoxifen administration from age P1-P4

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
exudative vitreoretinopathy DOID:0050535 OMIM:PS133780
 J:328283




Genotype
MGI:5445989
cn2
Allelic
Composition		 Cdh5tm1Dvst/Cdh5tm1Dvst
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh5tm1Dvst mutation (0 available); any Cdh5 mutation (59 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:189010 )
• prominent endothelial hyper-sprouting
• detaching tip cells have poor cellular connections to the vascular plexus at the angiogenic front and show signs of increased motility

vision/eye
abnormal retina vasculature morphology ( J:189010 )
• prominent endothelial hyper-sprouting
• detaching tip cells have poor cellular connections to the vascular plexus at the angiogenic front and show signs of increased motility




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory