Analysis Tools
mortality/aging
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• no mice are recovered postnatally
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• some mice die between E10.5 and E12.5
• however, long-term supplementation of maternal diet with retinaldehyde survive postnatally
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embryo
| N |
• supplementation of maternal diet with retinaldehyde rescues embryonic defects
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• posterior to second arches
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• compacted cervical/upper trunk region at E9-E9.5
• supplementation of maternal diet with retinoic acid partially rescues embryonic defects
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• cervical mesoderm patterning is abnormal
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• at E9-E9.5
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• at E10.5
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• forelimb buds are hypoplastic or almost undetectable
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• embryos are sometimes necrotic at E10.5
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cardiovascular system
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• hearts exhibit no distinct left-right atria, misaligned putative ventricles, and poor myocardial trabeculation
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• mice exhibit abnormal blood stasis suggesting cardiovascular failure
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craniofacial
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• truncated nasal process
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• posterior to second arches
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facial cleft
(
J:177362
)
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• severe nasal/facial clefting at E12.5
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limbs/digits/tail
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• after long-term retinaldehyde treatment, mice exhibit distal limb defects with shortened digits and soft tissue syndactyly particularly evident for hindlimb digits
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• forelimb buds are hypoplastic or almost undetectable
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• in mice rescued by long-term retinaldehyde treatment particularly evident for hindlimb digits
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syndactyly
(
J:177362
)
|
• in mice rescued by long-term retinaldehyde treatment particularly evident for hindlimb digits
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vision/eye
small lens
(
J:177362
)
|
• despite developing intracranially, eyes are not visible at E12.5
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hearing/vestibular/ear
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• small, sometimes duplicated
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digestive/alimentary system
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• poor morphological differentiation
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• poor morphological differentiation
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growth/size/body
facial cleft
(
J:177362
)
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• severe nasal/facial clefting at E12.5
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• at E10.5
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behavior/neurological
endocrine/exocrine glands
liver/biliary system
nervous system
renal/urinary system
respiratory system
absent lungs
(
J:177362
)
