Phenotypes associated with this allele

• Allele Symbol: S1pr1^tm1Cys
• Allele Name: targeted mutation 1, Jason G Cyster
• Allele ID: MGI:5295050
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	S1pr1^tm1Cys/S1pr1^tm1Cys	involves: 129P2/OlaHsd * C57BL/6	MGI:5295052

Genotype
MGI:5295052

hm1

• Allelic Composition: S1pr1^tm1Cys/S1pr1^tm1Cys
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:176118 )

N • mice exhibit normal numbers of follicular and marginal zone B cells

N • T and B cell lymph node entry is normal

decreased B cell number ( J:176118 )

• in the blood

abnormal B cell physiology ( J:176118 )

• marginal zone B cells are resistant to S1P-mediated S1PR1 internalization

• marginal zone B cells exhibit increased chemotaxis response to S1P compared with control cells

• splenic follicular dendritic cells exhibit reduced deposition of phycoerythrin-induced immune complexes compared with control cells

• however, chemotaxis response to CXCL12 and CXCL13 is normal

hematopoietic system

decreased B cell number ( J:176118 )

• in the blood

abnormal B cell physiology ( J:176118 )

• marginal zone B cells are resistant to S1P-mediated S1PR1 internalization

• marginal zone B cells exhibit increased chemotaxis response to S1P compared with control cells

• splenic follicular dendritic cells exhibit reduced deposition of phycoerythrin-induced immune complexes compared with control cells

• however, chemotaxis response to CXCL12 and CXCL13 is normal