Phenotypes associated with this allele

• Allele Symbol: Rln3^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:5295187
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rln3^tm1Lex/Rln3^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5310644

Genotype
MGI:5310644

hm1

• Allelic Composition: Rln3^tm1Lex/Rln3^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:177334 )

N • mice exhibit normal interaction with a novel object, motor coordination (rotarod), anxiety (light/dark box, elevated plus maze, large open field), spatial memory (Y-maze), or sensorimotor gating (prepulse inhibition)

behavioral despair ( J:177334 )

• male mice spend more time immobilized in a forced swim test compared with wild-type mice

decreased locomotor activity ( J:177334 )

• female mice exhibit fewer moves in a 26- by 26-cm automated locomotor cell, open field and novel object tests compared with wild-type mice

• female mice travel less distance in a novel object test compared with wild-type mice

• however, male mice exhibit normal activity

abnormal social investigation ( J:177334 )

• mice exhibit fewer interactions with a novel mice compared with wild-type mice

• however, interaction with a novel object is normal

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:181242 )

• in mice fed a breeding diet

decreased circulating insulin level ( J:181242 )

• at 10 to 15 weeks in female mice fed a breeding diet

• at 30 to 35 weeks in male and female mice fed a breeding diet

decreased circulating leptin level ( J:181242 )

• at 10 to 15 or 30 to 35 weeks in male and female mice fed a breeding diet

increased adiponectin level ( J:181242 )

• at 10 to 15 or 30 to 35 weeks in female mice fed a breeding diet

adipose tissue

decreased subcutaneous adipose tissue amount ( J:181242 )

• to a greater extent in male mice than female mice fed a breeding diet

decreased total body fat amount ( J:181242 )

• in mice fed a breeding diet

decreased mesenteric fat pad weight ( J:181242 )

• to a greater extent in male mice than female mice fed a breeding diet

growth/size/body

decreased susceptibility to diet-induced obesity ( J:181242 )

• in mice fed a breeding diet

decreased body size ( J:181242 )

• smaller and leaner than wild-type mice fed a breeding diet

decreased body weight ( J:177334 , J:181242 )

• male mice exhibit greater weight loss and impaired recovery from stress-induced weight loss compared with wild-type mice (J:177334)

• however, mice exhibit normal body weight under normal conditions (J:177334)

• to a greater extent in male mice than female mice fed a breeding diet (J:181242)

integument

decreased subcutaneous adipose tissue amount ( J:181242 )

• to a greater extent in male mice than female mice fed a breeding diet