All Phenotypes L1cam<tm1.1Pfm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	L1cam^tm1.1Pfm/L1cam^tm1.1Pfm	Not Specified	MGI:5295221
ot2	L1cam^tm1.1Pfm/Y	Not Specified	MGI:5295222

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:131051 )

N	• unlike null mice, the size and morphology of the superior colliculus, neocortex, hippocampus, thalamus, and cerebellum are normal

abnormal axon guidance ( J:131051 )

• retinal ganglion cell axons exhibit targeting errors, mostly as multiple ectopic terminationzones, along the mediolateral axis of the contralateral superior colliculus

• temporal and ventrotemporal retinal axons are misprojected along the mediolateral superior colliculus axis to inappropriate lateral positions and slight anteroposterior malpositioning

• retinal axons exhibit misdirected interstitial branching during development

abnormal axon morphology ( J:131051 )

• increased branching

• however, primary axon length and dendritic morphology are normal

abnormal retina ganglion cell morphology ( J:131051 )

• retinal ganglion cell axons exhibit targeting errors, mostly as multiple ectopic terminationzones, along the mediolateral axis of the contralateral superior colliculus

• temporal and ventrotemporal retinal axons are misprojected along the mediolateral superior colliculus axis to inappropriate lateral positions and slight anteroposterior malpositioning

• retinal axons exhibit misdirected interstitial branching during development

vision/eye

abnormal retina ganglion cell morphology ( J:131051 )

• retinal ganglion cell axons exhibit targeting errors, mostly as multiple ectopic terminationzones, along the mediolateral axis of the contralateral superior colliculus

• temporal and ventrotemporal retinal axons are misprojected along the mediolateral superior colliculus axis to inappropriate lateral positions and slight anteroposterior malpositioning

• retinal axons exhibit misdirected interstitial branching during development

cellular

abnormal axon guidance ( J:131051 )

• retinal ganglion cell axons exhibit targeting errors, mostly as multiple ectopic terminationzones, along the mediolateral axis of the contralateral superior colliculus

• temporal and ventrotemporal retinal axons are misprojected along the mediolateral superior colliculus axis to inappropriate lateral positions and slight anteroposterior malpositioning

• retinal axons exhibit misdirected interstitial branching during development

Allelic Composition	L1cam^tm1.1Pfm/Y
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
L1cam^tm1.1Pfm mutation (0 available); any L1cam mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:131051 )

N	• unlike null mice, the size and morphology of the superior colliculus, neocortex, hippocampus, thalamus, and cerebellum are normal

abnormal axon guidance ( J:131051 )

• retinal ganglion cell axons exhibit targeting errors, mostly as multiple ectopic terminationzones, along the mediolateral axis of the contralateral superior colliculus

• temporal and ventrotemporal retinal axons are misprojected along the mediolateral superior colliculus axis to inappropriate lateral positions and slight anteroposterior malpositioning

• retinal axons exhibit misdirected interstitial branching during development

abnormal retina ganglion cell morphology ( J:131051 )

• retinal ganglion cell axons exhibit targeting errors, mostly as multiple ectopic terminationzones, along the mediolateral axis of the contralateral superior colliculus

• temporal and ventrotemporal retinal axons are misprojected along the mediolateral superior colliculus axis to inappropriate lateral positions and slight anteroposterior malpositioning

• retinal axons exhibit misdirected interstitial branching during development

vision/eye

abnormal retina ganglion cell morphology ( J:131051 )

• retinal ganglion cell axons exhibit targeting errors, mostly as multiple ectopic terminationzones, along the mediolateral axis of the contralateral superior colliculus

• temporal and ventrotemporal retinal axons are misprojected along the mediolateral superior colliculus axis to inappropriate lateral positions and slight anteroposterior malpositioning

• retinal axons exhibit misdirected interstitial branching during development

cellular

abnormal axon guidance ( J:131051 )

• retinal ganglion cell axons exhibit targeting errors, mostly as multiple ectopic terminationzones, along the mediolateral axis of the contralateral superior colliculus

• temporal and ventrotemporal retinal axons are misprojected along the mediolateral superior colliculus axis to inappropriate lateral positions and slight anteroposterior malpositioning

• retinal axons exhibit misdirected interstitial branching during development

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