Phenotypes associated with this allele

• Allele Symbol: Zeb1^tm1.1Ajg
• Allele Name: targeted mutation 1.1, Andrew J Griffith
• Allele ID: MGI:5295192
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zeb1^tm1.1Ajg/Zeb1^tm1.1Ajg	C57BL/6-Zeb1^tm1.1Ajg	MGI:5295202
ht2	Zeb1^tm1.1Ajg/Zeb1^Tw	B6.Cg-Zeb1^tm1.1Ajg/Zeb1^Tw	MGI:5295203
ht3	Zeb1^tm1.1Ajg/Zeb1^tm2.1Ajg	C57BL/6-Zeb1^tm1.1Ajg/Zeb1^tm2.1Ajg	MGI:5295201

Genotype
MGI:5295202

hm1

• Allelic Composition: Zeb1^tm1.1Ajg/Zeb1^tm1.1Ajg
• Genetic Background: C57BL/6-Zeb1^tm1.1Ajg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ear abnormalities in Zeb1^tm2.1Ajg/Zeb1^tm1.1Ajg and Zeb1^tm1.1Ajg/Zeb1^tm1.1Ajg mice

hearing/vestibular/ear

decreased cochlea coiling ( J:177274 )

• shortening of the cochlear duct

abnormal semicircular canal morphology ( J:177274 )

• discontinuous or partially ruptured semicircular canals

absent lateral semicircular canal ( J:177274 )

decreased posterior semicircular canal size ( J:177274 )

• truncated

craniofacial

cleft palate ( J:177274 )

• in 50% of mice

digestive/alimentary system

cleft palate ( J:177274 )

• in 50% of mice

growth/size/body

cleft palate ( J:177274 )

• in 50% of mice

Genotype
MGI:5295203

ht2

• Allelic Composition: Zeb1^tm1.1Ajg/Zeb1^Tw
• Genetic Background: B6.Cg-Zeb1^tm1.1Ajg/Zeb1^Tw

Inner ear abnormalities in Zeb1^tm1.1Ajg/Zeb1^Tw mice

hearing/vestibular/ear

abnormal cochlea morphology ( J:177274 )

• shortening of the cochlear duct

abnormal semicircular canal morphology ( J:177274 )

• discontinuous or ruptured semicircular canals

craniofacial

cleft palate ( J:177274 )

• in 90% of mice

digestive/alimentary system

cleft palate ( J:177274 )

• in 90% of mice

growth/size/body

cleft palate ( J:177274 )

• in 90% of mice

Genotype
MGI:5295201

ht3

• Allelic Composition: Zeb1^tm1.1Ajg/Zeb1^tm2.1Ajg
• Genetic Background: C57BL/6-Zeb1^tm1.1Ajg/Zeb1^tm2.1Ajg

Ear abnormalities in Zeb1^tm2.1Ajg/Zeb1^tm1.1Ajg and Zeb1^tm1.1Ajg/Zeb1^tm1.1Ajg mice

behavior/neurological

behavior/neurological phenotype ( J:177274 )

N • unlike mice heterozygous for Zeb1^Tw, circling is not seen

abnormal eating behavior ( J:177274 )

• after 11 and 17 weeks of age in males and females respectively

decreased locomotor activity ( J:177274 )

• decrease in the number of beam breaks per hour

growth/size/body

increased body weight ( J:177274 )

• after 14 and 19 weeks of age in males and females, respectively

adipose tissue

increased total body fat amount ( J:177274 )

increased percent body fat/body weight ( J:177274 )

homeostasis/metabolism

abnormal circulating hormone level ( J:177274 )

increased circulating insulin level ( J:177274 )

increased circulating leptin level ( J:177274 )

abnormal circulating lipid level ( J:177274 )

increased circulating corticosterone level ( J:177274 )

increased circulating free fatty acids level ( J:177274 )

• in females

increased circulating triglyceride level ( J:177274 )

decreased oxygen consumption ( J:177274 )

• in females when normalized for body weight

impaired glucose tolerance ( J:177274 )

• slight glucose intolerance at 25 weeks of age in females

insulin resistance ( J:177274 )

• at 25 weeks of age in females

increased circulating adiponectin level ( J:177274 )

• elevated in the serum

hearing/vestibular/ear

abnormal semicircular canal morphology ( J:177274 )

• the contours of the canals are irregular

enlarged otoliths ( J:177274 )

• utricles have giant otoconia visible by scanning electron microscopy