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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nfatc1tm1Rao
targeted mutation 1, Anjana Rao
MGI:5295237
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Nfatc1tm1Rao/Nfatc1tm1Rao
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c MGI:5295253
cn2
Nfatc1tm1Rao/Nfatc1tm1Rao
Nfatc2tm1Rao/Nfatc2tm1Rao
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c MGI:5295256
cn3
Nfatc1tm1Rao/Nfatc1tm1Rao
Tg(Fcer2a-cre)5Mbu/0
involves: C57BL/6 * CBA MGI:5295254


Genotype
MGI:5295253
cn1
Allelic
Composition
Nfatc1tm1Rao/Nfatc1tm1Rao
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Nfatc1tm1Rao mutation (0 available); any Nfatc1 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• B cells exhibit reduced alpha-IgM-mediated calcium flux compared with control cells

immune system
• alpha-IgM-mediated
• following BCR-induction
• mild defects in alpha-IgM-mediated proliferation
• to IgG3 induced by T cell-independent type II antigens
• in the spleen
• 5- to 10-fold in peritoneal washes
• B cells exhibit reduced alpha-IgM-mediated calcium flux compared with control cells
• marginal zone B cells exhibit decreased TNP-Ficoll binding compared with wild-type cells

hematopoietic system
• alpha-IgM-mediated
• following BCR-induction
• mild defects in alpha-IgM-mediated proliferation
• to IgG3 induced by T cell-independent type II antigens
• in the spleen
• 5- to 10-fold in peritoneal washes
• B cells exhibit reduced alpha-IgM-mediated calcium flux compared with control cells
• marginal zone B cells exhibit decreased TNP-Ficoll binding compared with wild-type cells

cellular
• alpha-IgM-mediated
• following BCR-induction
• mild defects in alpha-IgM-mediated proliferation




Genotype
MGI:5295256
cn2
Allelic
Composition
Nfatc1tm1Rao/Nfatc1tm1Rao
Nfatc2tm1Rao/Nfatc2tm1Rao
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Nfatc1tm1Rao mutation (0 available); any Nfatc1 mutation (49 available)
Nfatc2tm1Rao mutation (3 available); any Nfatc2 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• stimulated B cells exhibit reduced ability to induced T cell proliferation
• from stimulated B cells

hematopoietic system
• stimulated B cells exhibit reduced ability to induced T cell proliferation




Genotype
MGI:5295254
cn3
Allelic
Composition
Nfatc1tm1Rao/Nfatc1tm1Rao
Tg(Fcer2a-cre)5Mbu/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc1tm1Rao mutation (0 available); any Nfatc1 mutation (49 available)
Tg(Fcer2a-cre)5Mbu mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• stimulated B cells exhibit reduced ability to induced T cell proliferation
• alpha-IgM-mediated
• however, LPS-stimulated B cell proliferation is normal
• to IgG3 induced by T cell-independent type II antigens
• after immunization with NP-KLH
• 10-fold after immunization with NP-Ficoll
• after immunization with NP-Ficoll
• in unstimulated B cells
• from LPS-stimulated B cells
• from stimulated B cells

hematopoietic system
• stimulated B cells exhibit reduced ability to induced T cell proliferation
• alpha-IgM-mediated
• however, LPS-stimulated B cell proliferation is normal
• to IgG3 induced by T cell-independent type II antigens
• after immunization with NP-KLH
• 10-fold after immunization with NP-Ficoll
• after immunization with NP-Ficoll
• in unstimulated B cells

cellular
• alpha-IgM-mediated
• however, LPS-stimulated B cell proliferation is normal





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory