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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfatc1tm1Rao
targeted mutation 1, Anjana Rao
MGI:5295237
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nfatc1tm1Rao/Nfatc1tm1Rao
Cd79atm1(cre)Reth/Cd79a+ 		involves: BALB/c MGI:5295253
cn2
 		Nfatc1tm1Rao/Nfatc1tm1Rao
Nfatc2tm1Rao/Nfatc2tm1Rao
Cd79atm1(cre)Reth/Cd79a+ 		involves: BALB/c MGI:5295256
cn3
 		Nfatc1tm1Rao/Nfatc1tm1Rao
Tg(Fcer2a-cre)5Mbu/0 		involves: C57BL/6 * CBA MGI:5295254


Genotype
MGI:5295253
cn1
Allelic
Composition		 Nfatc1tm1Rao/Nfatc1tm1Rao
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Nfatc1tm1Rao mutation (0 available); any Nfatc1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal B cell calcium ion homeostasis ( J:177319 )
• B cells exhibit reduced alpha-IgM-mediated calcium flux compared with control cells

immune system
increased B cell apoptosis ( J:177319 )
• alpha-IgM-mediated
decreased B cell proliferation ( J:177319 )
• following BCR-induction
• mild defects in alpha-IgM-mediated proliferation
abnormal class switch recombination ( J:177319 )
• to IgG3 induced by T cell-independent type II antigens
decreased B cell number ( J:177319 )
• in the spleen
decreased B-1a cell number ( J:177319 )
• 5- to 10-fold in peritoneal washes
abnormal B cell calcium ion homeostasis ( J:177319 )
• B cells exhibit reduced alpha-IgM-mediated calcium flux compared with control cells
abnormal marginal zone B cell physiology ( J:177319 )
• marginal zone B cells exhibit decreased TNP-Ficoll binding compared with wild-type cells

hematopoietic system
increased B cell apoptosis ( J:177319 )
• alpha-IgM-mediated
decreased B cell proliferation ( J:177319 )
• following BCR-induction
• mild defects in alpha-IgM-mediated proliferation
abnormal class switch recombination ( J:177319 )
• to IgG3 induced by T cell-independent type II antigens
decreased B cell number ( J:177319 )
• in the spleen
decreased B-1a cell number ( J:177319 )
• 5- to 10-fold in peritoneal washes
abnormal B cell calcium ion homeostasis ( J:177319 )
• B cells exhibit reduced alpha-IgM-mediated calcium flux compared with control cells
abnormal marginal zone B cell physiology ( J:177319 )
• marginal zone B cells exhibit decreased TNP-Ficoll binding compared with wild-type cells

cellular
increased B cell apoptosis ( J:177319 )
• alpha-IgM-mediated
decreased B cell proliferation ( J:177319 )
• mild defects in alpha-IgM-mediated proliferation
• following BCR-induction




Genotype
MGI:5295256
cn2
Allelic
Composition		 Nfatc1tm1Rao/Nfatc1tm1Rao
Nfatc2tm1Rao/Nfatc2tm1Rao
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Nfatc1tm1Rao mutation (0 available); any Nfatc1 mutation (49 available)
Nfatc2tm1Rao mutation (3 available); any Nfatc2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:177319 )
• stimulated B cells exhibit reduced ability to induced T cell proliferation
decreased interleukin-2 secretion ( J:177319 )
• from stimulated B cells

hematopoietic system
abnormal B cell physiology ( J:177319 )
• stimulated B cells exhibit reduced ability to induced T cell proliferation




Genotype
MGI:5295254
cn3
Allelic
Composition		 Nfatc1tm1Rao/Nfatc1tm1Rao
Tg(Fcer2a-cre)5Mbu/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc1tm1Rao mutation (0 available); any Nfatc1 mutation (49 available)
Tg(Fcer2a-cre)5Mbu mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:177319 )
• stimulated B cells exhibit reduced ability to induced T cell proliferation
decreased B cell proliferation ( J:177319 )
• alpha-IgM-mediated
• however, LPS-stimulated B cell proliferation is normal
abnormal class switch recombination ( J:177319 )
• to IgG3 induced by T cell-independent type II antigens
decreased IgG2a level ( J:177319 )
• after immunization with NP-KLH
decreased IgG3 level ( J:177319 )
• 10-fold after immunization with NP-Ficoll
decreased IgM level ( J:177319 )
• after immunization with NP-Ficoll
increased IgM level ( J:177319 )
• in unstimulated B cells
increased interleukin-10 secretion ( J:177319 )
• from LPS-stimulated B cells
decreased interleukin-2 secretion ( J:177319 )
• from stimulated B cells

hematopoietic system
abnormal B cell physiology ( J:177319 )
• stimulated B cells exhibit reduced ability to induced T cell proliferation
decreased B cell proliferation ( J:177319 )
• alpha-IgM-mediated
• however, LPS-stimulated B cell proliferation is normal
abnormal class switch recombination ( J:177319 )
• to IgG3 induced by T cell-independent type II antigens
decreased IgG2a level ( J:177319 )
• after immunization with NP-KLH
decreased IgG3 level ( J:177319 )
• 10-fold after immunization with NP-Ficoll
decreased IgM level ( J:177319 )
• after immunization with NP-Ficoll
increased IgM level ( J:177319 )
• in unstimulated B cells

cellular
decreased B cell proliferation ( J:177319 )
• alpha-IgM-mediated
• however, LPS-stimulated B cell proliferation is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory