Phenotypes associated with this allele

• Allele Symbol: Reg3g^tm1.1Lvh
• Allele Name: targeted mutation 1.1, Lora Hooper
• Allele ID: MGI:5295366
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Reg3g^tm1.1Lvh/Reg3g^tm1.1Lvh	B6.129-Reg3g^tm1.1Lvh	MGI:5295377

Genotype
MGI:5295377

hm1

• Allelic Composition: Reg3g^tm1.1Lvh/Reg3g^tm1.1Lvh
• Genetic Background: B6.129-Reg3g^tm1.1Lvh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:177506 )

N • mice exhibit normal intestinal morphology

abnormal feces composition ( J:177506 )

• increased fecal IgA and albumin

• however, antibody treatment restores normal fecal IgA levels

abnormal gut flora balance ( J:177506 )

• mice exhibit a higher mucosal bacterial loads (gram-positive Firmicutes phylum [Lactobacillus, Eubacterium rectale, and segmented filamentous bacteria (SFB) groups]) compared with wild-type mice

• however, luminal bacterial loads are normal

abnormal intestine physiology ( J:177506 )

• intestinal permeability (measured by fecal albumin) is increased compared to in wild-type mice

immune system

immune system phenotype ( J:177506 )

N • mice exhibit normal numbers of Th17 and regulatory T cells

increased T-helper 1 cell number ( J:177506 )

• in the intestinal lamina propria

• however, antibody treatment restores normal IFN-gamma-producing Th1 cell numbers

increased IgA level ( J:177506 )

• mice exhibit increased IgA+ cells in the small intestinal lamina propria and increased fecal IgA compared with wild-type mice

• however, antibody treatment restores normal IgA cell numbers

hematopoietic system

increased T-helper 1 cell number ( J:177506 )

• in the intestinal lamina propria

• however, antibody treatment restores normal IFN-gamma-producing Th1 cell numbers

increased IgA level ( J:177506 )

• mice exhibit increased IgA+ cells in the small intestinal lamina propria and increased fecal IgA compared with wild-type mice

• however, antibody treatment restores normal IgA cell numbers