Phenotypes associated with this allele

• Allele Symbol: Lrrk2^tm1.2Npa
• Allele Name: targeted mutation 1.2, Novartis Pharma AG
• Allele ID: MGI:5295370
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrk2^tm1.2Npa/Lrrk2^tm1.2Npa	involves: BALB/c * C57BL/6J	MGI:5295392

Genotype
MGI:5295392

hm1

• Allelic Composition: Lrrk2^tm1.2Npa/Lrrk2^tm1.2Npa
• Genetic Background: involves: BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urine protein level ( J:176679 )

• in 22 month old female mice and 18 month old male mice

abnormal kidney morphology ( J:176679 )

• dark kidneys around 5 months of age

increased kidney weight ( J:176679 )

• in male mice starting around 5 months of age

abnormal proximal convoluted tubule morphology ( J:176679 )

• as early as 6 weeks after birth, mice exhibit localized microvacuolization consisting of accumulation of many small isometric vacuoles in the epithelial cells of the proximal tubules in the cortex and outer medulla

• microvacuoles become larger and more and more tubules are affected with age

• tubular degeneration at 8 months of age with extracellular deposition of lipofuscin

• at 2 months, kidneys exhibit an increase in the number and size of secondary lysosomes in some proximal tubules

• at 6 months, proximal tubules contain enlarged and increased number of secondary lysosomes

dilated renal tubule ( J:176679 )

• at 5 months of age

respiratory system

abnormal type II pneumocyte morphology ( J:176679 )

• microvascuolization in type II pneumocytes located within the alveolar-septal wall at 1.5 months of age

• from 2 and 6 months, type II pneumocytes exhibit increased number of lamellar bodies compared with wild-type cells

cardiovascular system

cardiovascular system phenotype ( J:176679 )

N • mice exhibit normal systolic blood pressure and heart rate

increased systemic arterial diastolic blood pressure ( J:176679 )

homeostasis/metabolism

increased urine protein level ( J:176679 )

• in 22 month old female mice and 18 month old male mice

pigmentation

lipofuscinosis ( J:176679 )

• in vacuolated epithelial cells of the proximal tubules in the cortex and outer medulla at 5 months

• extracellular deposition of lipofuscin at 8 months of age

nervous system

nervous system phenotype ( J:176679 )

N • mice exhibit no overt neuropathy in response to dopamine agonists/antagonists

behavior/neurological

behavior/neurological phenotype ( J:176679 )

N • mice exhibit normal locomotor response to dopamine agonists/antagonists

growth/size/body

increased kidney weight ( J:176679 )

• in male mice starting around 5 months of age