Phenotypes associated with this allele

• Allele Symbol: Lrrk2^tm2.1Npa
• Allele Name: targeted mutation 2.1, Novartis Pharma AG
• Allele ID: MGI:5295371
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrk2^tm2.1Npa/Lrrk2^tm2.1Npa	involves: BALB/c * C57BL/6J	MGI:5295393

Genotype
MGI:5295393

hm1

• Allelic Composition: Lrrk2^tm2.1Npa/Lrrk2^tm2.1Npa
• Genetic Background: involves: BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney morphology ( J:176679 )

• dark kidneys around 5 months of age

increased kidney weight ( J:176679 )

abnormal proximal convoluted tubule morphology ( J:176679 )

• between 1.5 and up to 8 months, mice exhibit localized microvacuolization consisting of accumulation of many small isometric vacuoles in the epithelial cells of the proximal tubules in the cortex and outer medulla

dilated renal tubule ( J:176679 )

• at 5 months of age

cardiovascular system

cardiovascular system phenotype ( J:176679 )

N • mice exhibit normal diastolic and diastolic blood pressure and heart rate

pigmentation

lipofuscinosis ( J:176679 )

• in vacuolated epithelial cells of the proximal tubules in the cortex and outer medulla at 5 and 8 months

respiratory system

respiratory system phenotype ( J:176679 )

N • mice exhibit normal lung histopathology

growth/size/body

increased kidney weight ( J:176679 )