All Phenotypes Hcn2<tm1.1Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hcn2^tm1.1Lex
targeted mutation 1.1, Lexicon Genetics
MGI:5295434

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hcn2^tm1.1Lex/Hcn2^tm1.1Lex Scn10a^tm2(cre)Jwo/Scn10a⁺	involves: 129 * C57BL/6	MGI:5295437

Allelic Composition	Hcn2^tm1.1Lex/Hcn2^tm1.1Lex Scn10a^tm2(cre)Jwo/Scn10a⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcn2^tm1.1Lex mutation (0 available); any Hcn2 mutation (29 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal touch/ nociception ( J:176663 )

• in a neuropathic pain model, mice do not exhibit heat or mechanical hyperalgesia or cold allodynia unlike similarly treated wild-type mice

• however, mechanical hyperalgesia is normal

increased chemical nociceptive threshold ( J:176663 )

• formalin-treated mice exhibit attenuated late phase pain response compared with similarly treated wild-type mice

abnormal nociception after inflammation ( J:176663 )

• thermal hyperalgesia after carrageenan injection to induce long-lasting inflammation is completely abolished

increased thermal nociceptive threshold ( J:176663 )

• PGE2-induced thermal hyperalgesia is abolished

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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