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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm4.1Fwa
targeted mutation 4.1, Frederick W Alt
MGI:5295439
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm4.1Fwa/Ightm4.1Fwa involves: 129S6/SvEvTac MGI:5295453
ht2
 		Ightm4.1Fwa/Igh+ involves: 129S6/SvEvTac MGI:5295454
ht3
 		Ightm2Cgn/Ightm4.1Fwa involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:5295455


Genotype
MGI:5295453
hm1
Allelic
Composition		 Ightm4.1Fwa/Ightm4.1Fwa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm4.1Fwa mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:176649 )
• mice exhibit a reduction in the ratio of pre-B to pro-B cells compared with wild-type mice
abnormal immunoglobulin V(D)J recombination ( J:176649 )
• mice exhibit increased VH7183 and decreased VHJ558 recombination in B lineage cells compared with wild-type mice
• mice exhibit defective VHD rearrangement in pro-B and double positive VHD recombination and lineage specific VH to DJH recombination

hematopoietic system
abnormal B cell differentiation ( J:176649 )
• mice exhibit a reduction in the ratio of pre-B to pro-B cells compared with wild-type mice
abnormal immunoglobulin V(D)J recombination ( J:176649 )
• mice exhibit increased VH7183 and decreased VHJ558 recombination in B lineage cells compared with wild-type mice
• mice exhibit defective VHD rearrangement in pro-B and double positive VHD recombination and lineage specific VH to DJH recombination




Genotype
MGI:5295454
ht2
Allelic
Composition		 Ightm4.1Fwa/Igh+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm4.1Fwa mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:176649 )
• mice exhibit a reduction in the ratio of pre-B to pro-B cells compared with wild-type mice
abnormal immunoglobulin V(D)J recombination ( J:176649 )
• mice exhibit defective VHD rearrangement in pro-B and double positive VHD recombination and lineage specific VH to DJH recombination

hematopoietic system
abnormal B cell differentiation ( J:176649 )
• mice exhibit a reduction in the ratio of pre-B to pro-B cells compared with wild-type mice
abnormal immunoglobulin V(D)J recombination ( J:176649 )
• mice exhibit defective VHD rearrangement in pro-B and double positive VHD recombination and lineage specific VH to DJH recombination




Genotype
MGI:5295455
ht3
Allelic
Composition		 Ightm2Cgn/Ightm4.1Fwa
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Cgn mutation (1 available); any Igh mutation (44 available)
Ightm4.1Fwa mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immunoglobulin V(D)J recombination ( J:176649 )
• the frequency of recombination is shifted and more non-productive rearrangements are produced

immune system
abnormal immunoglobulin V(D)J recombination ( J:176649 )
• the frequency of recombination is shifted and more non-productive rearrangements are produced




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory