About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm4.1Fwa
targeted mutation 4.1, Frederick W Alt
MGI:5295439
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm4.1Fwa/Ightm4.1Fwa involves: 129S6/SvEvTac MGI:5295453
ht2
 		Ightm4.1Fwa/Igh+ involves: 129S6/SvEvTac MGI:5295454
ht3
 		Ightm2Cgn/Ightm4.1Fwa involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:5295455


Genotype
MGI:5295453
hm1
Allelic
Composition		 Ightm4.1Fwa/Ightm4.1Fwa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm4.1Fwa mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:176649 )
• mice exhibit a reduction in the ratio of pre-B to pro-B cells compared with wild-type mice
abnormal immunoglobulin V(D)J recombination ( J:176649 )
• mice exhibit increased VH7183 and decreased VHJ558 recombination in B lineage cells compared with wild-type mice
• mice exhibit defective VHD rearrangement in pro-B and double positive VHD recombination and lineage specific VH to DJH recombination

hematopoietic system
abnormal B cell differentiation ( J:176649 )
• mice exhibit a reduction in the ratio of pre-B to pro-B cells compared with wild-type mice
abnormal immunoglobulin V(D)J recombination ( J:176649 )
• mice exhibit increased VH7183 and decreased VHJ558 recombination in B lineage cells compared with wild-type mice
• mice exhibit defective VHD rearrangement in pro-B and double positive VHD recombination and lineage specific VH to DJH recombination




Genotype
MGI:5295454
ht2
Allelic
Composition		 Ightm4.1Fwa/Igh+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm4.1Fwa mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:176649 )
• mice exhibit a reduction in the ratio of pre-B to pro-B cells compared with wild-type mice
abnormal immunoglobulin V(D)J recombination ( J:176649 )
• mice exhibit defective VHD rearrangement in pro-B and double positive VHD recombination and lineage specific VH to DJH recombination

hematopoietic system
abnormal B cell differentiation ( J:176649 )
• mice exhibit a reduction in the ratio of pre-B to pro-B cells compared with wild-type mice
abnormal immunoglobulin V(D)J recombination ( J:176649 )
• mice exhibit defective VHD rearrangement in pro-B and double positive VHD recombination and lineage specific VH to DJH recombination




Genotype
MGI:5295455
ht3
Allelic
Composition		 Ightm2Cgn/Ightm4.1Fwa
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Cgn mutation (1 available); any Igh mutation (44 available)
Ightm4.1Fwa mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immunoglobulin V(D)J recombination ( J:176649 )
• the frequency of recombination is shifted and more non-productive rearrangements are produced

immune system
abnormal immunoglobulin V(D)J recombination ( J:176649 )
• the frequency of recombination is shifted and more non-productive rearrangements are produced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory